Gilbert syndrome

Gilbert syndrome is an inherited condition that is usually harmless. It is characterized by higher than normal levels of unconjugated bilirubin in the blood, which can sometimes lead to episodes of mild jaundice. This condition is autosomal recessive, meaning that a person needs to inherit the gene change from both parents. The elevated bilirubin levels typically cause a noticeable but temporary yellowing of the skin and eyes, and this pattern tends to be intermittent rather than constant.

People with Gilbert syndrome may experience episodes of mild jaundice, which means that their skin and the whites of their eyes may turn a yellowish color. These episodes are usually intermittent and do not lead to serious health issues.

Gilbert syndrome is caused by changes in the UGT1A1 gene, which affects how the body processes bilirubin, a substance produced from the breakdown of red blood cells. It is inherited in an autosomal recessive manner, meaning that the gene change must be passed on by both parents.

Gilbert syndrome is generally harmless, meaning that people with this condition usually do not require specific treatments. Information about treatment is currently limited for this condition.

The outlook for people with Gilbert syndrome is very good. Although episodes of jaundice may occur, they are typically harmless and do not affect overall health or life expectancy.

Information about current research and future directions is currently limited for this condition.