About

Open resources for the rare disease community.

Kisho is a free, open resource for people living with rare conditions, their caregivers, and the clinicians who serve them. We pull data from 12 authoritative sources, normalize it against the MONDO disease ontology, and present it in plain language. Every fact traces back to its source. Nothing is paywalled.

The 12 sources we draw from

MONDO
Disease ontology — the canonical map of all human diseases.
GeneReviews
NIH-curated clinical chapters from the University of Washington.
ClinVar
Pathogenic variants and clinical significance from NCBI.
ClinGen
Gene-disease validity classifications.
FDA
Drug approvals, orphan designations, safety actions.
NIH RePORTER
Federal research grants and PIs.
ClinicalTrials.gov
Recruiting trials, study sites, sponsors.
PubMed
Peer-reviewed research.
Orphanet
European reference portal for rare diseases.
HPO
Human Phenotype Ontology — symptoms and clinical signs.
HGNC
Authorized gene symbols and chromosome locations.
Congress.gov
Federal and state legislation relevant to rare disease.

How we use this data

Every disease page on Kisho combines data from multiple sources into a single plain-language summary. We never invent facts. Where evidence is uncertain, we say so. Where a source updates, our page updates within hours. You can save any disease, patient organization, assistance program, company, trial, or bill to receive email updates when relevant news appears.

Questions or corrections? Get in touch.

Kisho

About

Open resources for the rare disease community.

The 12 sources we draw from

MONDO
Disease ontology — the canonical map of all human diseases.
GeneReviews
NIH-curated clinical chapters from the University of Washington.
ClinVar
Pathogenic variants and clinical significance from NCBI.
ClinGen
Gene-disease validity classifications.
FDA
Drug approvals, orphan designations, safety actions.
NIH RePORTER
Federal research grants and PIs.
ClinicalTrials.gov
Recruiting trials, study sites, sponsors.
PubMed
Peer-reviewed research.
Orphanet
European reference portal for rare diseases.
HPO
Human Phenotype Ontology — symptoms and clinical signs.
HGNC
Authorized gene symbols and chromosome locations.
Congress.gov
Federal and state legislation relevant to rare disease.

How we use this data

Questions or corrections? Get in touch.