X-linked complicated spastic paraplegia type 1

X-linked complicated spastic paraplegia type 1, also known as SPG1, is a rare form of L1 syndrome. People with this condition experience spastic paraplegia, which means stiffness and weakness in the legs, along with mild to moderate intellectual disability. The condition is called X-linked because it is linked to the X chromosome, affecting the way the body and brain develop in certain ways. In this condition, brain imaging studies such as MRI typically appear normal, even though the clinical symptoms are present. Information in this summary is based on the definition provided, and additional details about variations in presentation are not available at this time.

Common signs of the condition include spastic paraplegia, which causes stiffness and weakness in the legs, and mild to moderate intellectual disability that may affect learning and thinking skills. Brain scans, like MRIs, are usually normal despite these symptoms.

The condition is described as an X-linked form of L1 syndrome. This means it is related to the X chromosome, which is one of the two sex chromosomes. Detailed genetic information, including specific genes, is not available in the provided sources.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about research is currently limited for this condition.