MIT family translocation renal cell carcinoma

MIT family translocation renal cell carcinoma is a rare subtype of kidney cancer. It is characterized by genetic changes, specifically rearrangements in the TFE3 and TFEB genes. In t(6;11) cases, the tumor shows distinct features with two types of cells: larger epitheloid cells and smaller eosinophilic cells. People with this condition may have non-specific symptoms and signs, which makes it challenging to detect from just the appearance of the tumor. The information provided emphasizes the unique genetic changes associated with this rare type of renal cell carcinoma.

Common symptoms for MIT family translocation renal cell carcinoma include blood in the urine (hematuria), pain in the side (flank pain), a mass felt in the abdomen, and systemic symptoms such as low red blood cell count (anemia), tiredness, and fever. These signs are often non-specific and can overlap with other conditions.

This condition is caused by genetic abnormalities that lead to changes in kidney cells. The most notable genetic changes involve rearrangements in the TFE3 gene for Xp11 t-RCC and in the TFEB gene for t(6;11) t-RCC. These genetic rearrangements are key factors in the development of this rare renal cell carcinoma.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about research is currently limited for this condition.