Anterior cutaneous nerve entrapment syndrome (ACNES) is a chronic neuropathic pain syndrome of the abdominal wall caused by entrapment of anterior cutaneous branches of 7 to 12th intercostal nerves al...
Comprehensive, easy-to-understand information about this condition
How we create this content →The documentation on anterior cutaneous nerve entrapment syndrome is limited due to its rarity and the challenges in systematically studying conditions that affect fewer than 1 in 100,000 people. The lack of identified genetic factors and established inheritance patterns further complicates research efforts. As a result, clinical characterization is still ongoing, and many aspects of the condition remain poorly understood.
The clinical picture of anterior cutaneous nerve entrapment syndrome is dominated by abdominal pain, which is reported by 80-99% of patients. Associated symptoms include somatic sensory dysfunction and impaired tactile sensation, also affecting 80-99% of individuals. Other notable features include hyperhidrosis (30-79%), vertigo (30-79%), and gastrointestinal symptoms such as nausea and anorexia, occurring in 5-29% of cases. While back pain and abdominal distention are less common, they can be part of the clinical manifestation.
To navigate anterior cutaneous nerve entrapment syndrome, consider consulting a neurologist or pain specialist with experience in neuropathic pain syndromes. They can provide tailored management strategies. While there are currently no patient organizations specific to ACNES, resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can offer valuable information. Additionally, inquire about participation in clinical trials, as they may provide access to new treatments and contribute to the understanding of this condition.
Currently, there are no orphan drugs designated for anterior cutaneous nerve entrapment syndrome, but there is one active clinical trial available. Interested patients can explore participation in this trial for potential new insights and treatments. For more information on the active trial, please visit the ClinicalTrials.gov search page: https://clinicaltrials.gov/search?cond=anterior%20cutaneous%20nerve%20entrapment%20syndrome.
Actionable guidance for navigating care for anterior cutaneous nerve entrapment syndrome
To navigate anterior cutaneous nerve entrapment syndrome, consider consulting a neurologist or pain specialist with experience in neuropathic pain syndromes. They can provide tailored management strategies. While there are currently no patient organizations specific to ACNES, resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can offer valuable information. Additionally, inquire about participation in clinical trials, as they may provide access to new treatments and contribute to the understanding of this condition.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
The documentation on anterior cutaneous nerve entrapment syndrome is limited due to its rarity and the challenges in systematically studying conditions that affect fewer than 1 in 100,000 people. The lack of identified genetic factors and established inheritance patterns further complicates research efforts. As a result, clinical characterization is still ongoing, and many aspects of the condition remain poorly understood.
The clinical picture of anterior cutaneous nerve entrapment syndrome is dominated by abdominal pain, which is reported by 80-99% of patients. Associated symptoms include somatic sensory dysfunction and impaired tactile sensation, also affecting 80-99% of individuals. Other notable features include hyperhidrosis (30-79%), vertigo (30-79%), and gastrointestinal symptoms such as nausea and anorexia, occurring in 5-29% of cases. While back pain and abdominal distention are less common, they can be part of the clinical manifestation.
To navigate anterior cutaneous nerve entrapment syndrome, consider consulting a neurologist or pain specialist with experience in neuropathic pain syndromes. They can provide tailored management strategies. While there are currently no patient organizations specific to ACNES, resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can offer valuable information. Additionally, inquire about participation in clinical trials, as they may provide access to new treatments and contribute to the understanding of this condition.
Currently, there are no orphan drugs designated for anterior cutaneous nerve entrapment syndrome, but there is one active clinical trial available. Interested patients can explore participation in this trial for potential new insights and treatments. For more information on the active trial, please visit the ClinicalTrials.gov search page: https://clinicaltrials.gov/search?cond=anterior%20cutaneous%20nerve%20entrapment%20syndrome.
Actionable guidance for navigating care for anterior cutaneous nerve entrapment syndrome
To navigate anterior cutaneous nerve entrapment syndrome, consider consulting a neurologist or pain specialist with experience in neuropathic pain syndromes. They can provide tailored management strategies. While there are currently no patient organizations specific to ACNES, resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can offer valuable information. Additionally, inquire about participation in clinical trials, as they may provide access to new treatments and contribute to the understanding of this condition.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
The documentation on anterior cutaneous nerve entrapment syndrome is limited due to its rarity and the challenges in systematically studying conditions that affect fewer than 1 in 100,000 people. The lack of identified genetic factors and established inheritance patterns further complicates research efforts. As a result, clinical characterization is still ongoing, and many aspects of the condition remain poorly understood.
The clinical picture of anterior cutaneous nerve entrapment syndrome is dominated by abdominal pain, which is reported by 80-99% of patients. Associated symptoms include somatic sensory dysfunction and impaired tactile sensation, also affecting 80-99% of individuals. Other notable features include hyperhidrosis (30-79%), vertigo (30-79%), and gastrointestinal symptoms such as nausea and anorexia, occurring in 5-29% of cases. While back pain and abdominal distention are less common, they can be part of the clinical manifestation.
To navigate anterior cutaneous nerve entrapment syndrome, consider consulting a neurologist or pain specialist with experience in neuropathic pain syndromes. They can provide tailored management strategies. While there are currently no patient organizations specific to ACNES, resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can offer valuable information. Additionally, inquire about participation in clinical trials, as they may provide access to new treatments and contribute to the understanding of this condition.
Currently, there are no orphan drugs designated for anterior cutaneous nerve entrapment syndrome, but there is one active clinical trial available. Interested patients can explore participation in this trial for potential new insights and treatments. For more information on the active trial, please visit the ClinicalTrials.gov search page: https://clinicaltrials.gov/search?cond=anterior%20cutaneous%20nerve%20entrapment%20syndrome.
Actionable guidance for navigating care for anterior cutaneous nerve entrapment syndrome
To navigate anterior cutaneous nerve entrapment syndrome, consider consulting a neurologist or pain specialist with experience in neuropathic pain syndromes. They can provide tailored management strategies. While there are currently no patient organizations specific to ACNES, resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov can offer valuable information. Additionally, inquire about participation in clinical trials, as they may provide access to new treatments and contribute to the understanding of this condition.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
Clinical profile data for this condition is not yet available. Phenotype information may still be loading below.
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 6, 2026
Consider asking your healthcare providers these condition-specific questions
European rare disease database
Genetic and Rare Diseases Info Center
AI-Generated Content: This summary was generated using AI. Always consult with qualified healthcare providers for medical guidance.
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