Any Cushing syndrome caused by body's prolonged overproduction of cortisol that can be dependent on or independent of adrenocorticotropic hormone (ACTH).
Comprehensive, easy-to-understand information about this condition
How we create this content →The documentation surrounding endogenous Cushing syndrome is limited due to its rarity and the complexity of its clinical features. As this condition affects a small population, systematic studies have been scarce, making it difficult to establish comprehensive clinical guidelines or genetic insights.
To navigate your care effectively, consider consulting an endocrinologist with experience in Cushing syndrome management. They can provide tailored guidance and treatment options. Additionally, you can explore resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov for further information. Participating in clinical trials may also be beneficial, and you can find opportunities through the ClinicalTrials.gov link provided. While no patient organizations are currently identified, connecting with specialists can help you find support networks.
There are currently five active clinical trials investigating treatments for endogenous Cushing syndrome. Notably, two FDA-approved drugs, levoketoconazole and osilodrostat, are available for managing the condition. Additionally, two drugs, clofutriben and relacorilant, have been designated as orphan drugs and are in development. For more information on ongoing trials, you can visit ClinicalTrials.gov at https://clinicaltrials.gov/search?cond=endogenous%20Cushing%20syndrome.
Actionable guidance for navigating care for endogenous Cushing syndrome
To navigate your care effectively, consider consulting an endocrinologist with experience in Cushing syndrome management. They can provide tailored guidance and treatment options. Additionally, you can explore resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov for further information. Participating in clinical trials may also be beneficial, and you can find opportunities through the ClinicalTrials.gov link provided. While no patient organizations are currently identified, connecting with specialists can help you find support networks.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
The documentation surrounding endogenous Cushing syndrome is limited due to its rarity and the complexity of its clinical features. As this condition affects a small population, systematic studies have been scarce, making it difficult to establish comprehensive clinical guidelines or genetic insights.
To navigate your care effectively, consider consulting an endocrinologist with experience in Cushing syndrome management. They can provide tailored guidance and treatment options. Additionally, you can explore resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov for further information. Participating in clinical trials may also be beneficial, and you can find opportunities through the ClinicalTrials.gov link provided. While no patient organizations are currently identified, connecting with specialists can help you find support networks.
There are currently five active clinical trials investigating treatments for endogenous Cushing syndrome. Notably, two FDA-approved drugs, levoketoconazole and osilodrostat, are available for managing the condition. Additionally, two drugs, clofutriben and relacorilant, have been designated as orphan drugs and are in development. For more information on ongoing trials, you can visit ClinicalTrials.gov at https://clinicaltrials.gov/search?cond=endogenous%20Cushing%20syndrome.
Actionable guidance for navigating care for endogenous Cushing syndrome
To navigate your care effectively, consider consulting an endocrinologist with experience in Cushing syndrome management. They can provide tailored guidance and treatment options. Additionally, you can explore resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov for further information. Participating in clinical trials may also be beneficial, and you can find opportunities through the ClinicalTrials.gov link provided. While no patient organizations are currently identified, connecting with specialists can help you find support networks.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
The documentation surrounding endogenous Cushing syndrome is limited due to its rarity and the complexity of its clinical features. As this condition affects a small population, systematic studies have been scarce, making it difficult to establish comprehensive clinical guidelines or genetic insights.
To navigate your care effectively, consider consulting an endocrinologist with experience in Cushing syndrome management. They can provide tailored guidance and treatment options. Additionally, you can explore resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov for further information. Participating in clinical trials may also be beneficial, and you can find opportunities through the ClinicalTrials.gov link provided. While no patient organizations are currently identified, connecting with specialists can help you find support networks.
There are currently five active clinical trials investigating treatments for endogenous Cushing syndrome. Notably, two FDA-approved drugs, levoketoconazole and osilodrostat, are available for managing the condition. Additionally, two drugs, clofutriben and relacorilant, have been designated as orphan drugs and are in development. For more information on ongoing trials, you can visit ClinicalTrials.gov at https://clinicaltrials.gov/search?cond=endogenous%20Cushing%20syndrome.
Actionable guidance for navigating care for endogenous Cushing syndrome
To navigate your care effectively, consider consulting an endocrinologist with experience in Cushing syndrome management. They can provide tailored guidance and treatment options. Additionally, you can explore resources such as the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov for further information. Participating in clinical trials may also be beneficial, and you can find opportunities through the ClinicalTrials.gov link provided. While no patient organizations are currently identified, connecting with specialists can help you find support networks.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
Clinical profile data for this condition is not yet available. Phenotype information may still be loading below.
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 31, 2026
Consider asking your healthcare providers these condition-specific questions
European rare disease database
AI-Generated Content: This summary was generated using AI. Content has been fact-checked. Always consult with qualified healthcare providers for medical guidance.
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