Genetic testing for ENAM is available. Testing is considered confirmatory for diagnosis.

Phenotype severity distribution: 2 always present features.

No clinical trials have been registered for amelogenesis imperfecta type 1C.

103 publications have been identified in PubMed for amelogenesis imperfecta type 1C. Kisho has analyzed 77 by research type. Research spans Review / Meta-Analysis (36%), Epidemiology / Natural History (35%), and Case Report / Case Series (17%).

Recent Publications

• Auwerx H (2026). [PMID: 41636123](https://pubmed.ncbi.nlm.nih.gov/41636123/). *Acta Physiol (Oxf)*. [Basic Science / Preclinical]

• Araujo EA (2026). [PMID: 41539874](https://pubmed.ncbi.nlm.nih.gov/41539874/). *J World Fed Orthod*. [Case Report / Case Series]

• Díaz-Fabregat B (2026). [PMID: 42093537](https://pubmed.ncbi.nlm.nih.gov/42093537/). *J Hum Lact*. [Review / Meta-Analysis]

• Raghavan S (2026). [PMID: 41740246](https://pubmed.ncbi.nlm.nih.gov/41740246/). *Int Dent J*. [Review / Meta-Analysis]

• Abu Arqub S (2026). [PMID: 41638603](https://pubmed.ncbi.nlm.nih.gov/41638603/). *Angle Orthod*. [Epidemiology / Natural History]

• Faryad A (2026). [PMID: 41590179](https://pubmed.ncbi.nlm.nih.gov/41590179/). *Dent J (Basel)*. [Review / Meta-Analysis]

• D'Antò V (2025). [PMID: 40760282](https://pubmed.ncbi.nlm.nih.gov/40760282/). *Prog Orthod*. [Review / Meta-Analysis]

• Gao C (2025). [PMID: 40619361](https://pubmed.ncbi.nlm.nih.gov/40619361/). *BMC Oral Health*. [Review / Meta-Analysis]

• Zhao T (2025). [PMID: 40699159](https://pubmed.ncbi.nlm.nih.gov/40699159/). *Am J Orthod Dentofacial Orthop*. [Review / Meta-Analysis]

• Qu G (2025). [PMID: 39734269](https://pubmed.ncbi.nlm.nih.gov/39734269/). *J Oral Rehabil*. [Epidemiology / Natural History]