Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

amyotrophic lateral sclerosis type 3 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

amyotrophic lateral sclerosis type 3

MONDO:0011691

Also known as:amyotrophic lateral sclerosis 3ALS3

Overview

GeneticsAutosomal dominant

ResearchLimited published research (4 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Bulbar signs and Lower limb muscle weakness. 4 total HPO annotations.

Organ System	Phenotype Count	Example Features
Muscles	2	Shrinkage of the cerebellum (cerebellar atrophy), Lower limb muscle weakness

Prognosis

Phenotype severity distribution: 2 always present features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for amyotrophic lateral sclerosis type 3.

4 publications have been identified in PubMed for amyotrophic lateral sclerosis type 3. Research spans Case Report / Case Series (75%) and Review / Meta-Analysis (25%).

Recent Publications

Weinhofer I (2025). [PMID: 40325881](https://pubmed.ncbi.nlm.nih.gov/40325881/). *J Inherit Metab Dis*. [Review / Meta-Analysis]
Takubo M (2025). [PMID: 41224274](https://pubmed.ncbi.nlm.nih.gov/41224274/). *Intern Med*. [Case Report / Case Series]
Soliman R (2025). [PMID: 40075315](https://pubmed.ncbi.nlm.nih.gov/40075315/). *J Headache Pain*. [Case Report / Case Series]
Hu X (2025). [PMID: 40128246](https://pubmed.ncbi.nlm.nih.gov/40128246/). *Sci Rep*. [Case Report / Case Series]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:01 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:606640

GARD

Genetic and Rare Diseases Info Center

GARD:10501

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

amyotrophic lateral sclerosis type 3

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features