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Features include very common findings: Left-to-right shunt; and common findings: Palpitations, Exertional dyspnea, Exercise intolerance, and Fatigue and others. 35 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Heart and blood vessels | 18 | Right atrial enlargement, Systolic heart murmur, Abnormal mitral valve morphology |
Biomarker and diagnostic research for atrial septal defect, ostium secundum type has been reported in the published literature.
Phenotype severity distribution: 1 very common feature, 6 common features.
No clinical trials have been registered for atrial septal defect, ostium secundum type.
12 publications have been identified in PubMed for atrial septal defect, ostium secundum type. Research spans Case Report / Case Series (50%), Clinical Trial Publication (25%), and Diagnostic / Biomarker (8%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 6 | 50% |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:13 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Lungs and breathing
6 |
Exertional dyspnea, High blood pressure in lung arteries (pulmonary arterial hypertension), Dyspnea |
Brain and nerves | 5 | Exercise intolerance, Fatigue, ST segment depression |
Blood and immune system | 1 | Recurrent bacterial infections |
Clinical study results
3 |
25% |
Testing and diagnosis research | 1 | 8% |
Research summaries | 1 | 8% |
Disease patterns and progression | 1 | 8% |
Pérez-Riera AR (2026). [PMID: 41916230](https://pubmed.ncbi.nlm.nih.gov/41916230/). *Journal of electrocardiology*. [Case Report / Case Series]
Albenque G (2026). [PMID: 40957780](https://pubmed.ncbi.nlm.nih.gov/40957780/). *Archives of cardiovascular diseases*. [Clinical Trial Publication]
Shah B (2025). [PMID: 40510059](https://pubmed.ncbi.nlm.nih.gov/40510059/). *Cureus*. [Case Report / Case Series]
de Liyis BG (2025). [PMID: 38597284](https://pubmed.ncbi.nlm.nih.gov/38597284/). *Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists*. [Review / Meta-Analysis]
Lee J (2025). [PMID: 41346806](https://pubmed.ncbi.nlm.nih.gov/41346806/). *Frontiers in veterinary science*. [Case Report / Case Series]
Yousuf Q (2025). [PMID: 41130731](https://pubmed.ncbi.nlm.nih.gov/41130731/). *BMJ case reports*. [Case Report / Case Series]
Nasir M (2025). [PMID: 40041170](https://pubmed.ncbi.nlm.nih.gov/40041170/). *Frontiers in cardiovascular medicine*. [Clinical Trial Publication]
Munteanu IR (2025). [PMID: 40981143](https://pubmed.ncbi.nlm.nih.gov/40981143/). *Reports (MDPI)*. [Case Report / Case Series]
Rangosch A (2024). [PMID: 39220352](https://pubmed.ncbi.nlm.nih.gov/39220352/). *Methodist DeBakey cardiovascular journal*. [Diagnostic / Biomarker]
Viera E (2024). [PMID: 39265799](https://pubmed.ncbi.nlm.nih.gov/39265799/). *The American journal of cardiology*. [Epidemiology / Natural History]