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autosomal dominant nonsyndromic hearing loss 12 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

autosomal dominant nonsyndromic hearing loss 12

MONDO:0011102

Also known as:DFNA12DFNA8TECTA autosomal dominant nonsyndromic deafness

Overview

Any autosomal dominant nonsyndromic deafness in which the cause of the disease is a mutation in the TECTA gene.

GeneticsAutosomal dominant · TECTA (chr 11)

Clinical Presentation

Features include: Inner ear hearing loss (sensorineural hearing impairment).

Organ System	Phenotype Count	Example Features
Ears	1	Inner ear hearing loss (sensorineural hearing impairment)

Explore clinical features

Genetic Landscape

TECTA function has not been fully characterized.

Autosomal dominant nonsyndromic hearing loss 12 is associated with mutations in the TECTA gene on chromosome 11.

Diagnosis

Drawn from GeneReviews diagnostic guidelines, newborn screening panel status (RUSP), and ClinGen gene-disease validity classifications. Reflects current clinical evidence and consensus where available.

Genetic testing for TECTA is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for autosomal dominant nonsyndromic hearing loss 12 has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for autosomal dominant nonsyndromic hearing loss 12.

26 publications have been identified in PubMed for autosomal dominant nonsyndromic hearing loss 12. Research spans Basic Science / Preclinical (38%), Case Report / Case Series (29%), and Diagnostic / Biomarker (13%).

Research Type	Count	% of Total
Laboratory research	9	38%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 10:45 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:601543

GARD

Genetic and Rare Diseases Info Center

GARD:18107

Questions for Your Care Team

→Should I pursue genetic testing for TECTA, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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autosomal dominant nonsyndromic hearing loss 12

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

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Questions for Your Care Team

Questions for Your Care Team

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