Spinal Cord Injury — NIH Grants & Funding

MONDO:0043797

Funding Landscape

Spinal Cord Injury has a robust NIH research funding landscape with 218 funded grants and $196.0M in total funding over the period.

218funded grants from NIH

Portfolio: $99.3MCumulative: $196.0M140 active78 completed223 PIs85 institutions

+6% YoY(FY2024 vs FY2025)

33 new grants started in the last 12 months.

By Research Theme

Basic Science

107

Clinical

Translational

Gene/Cell Therapy

Medical Device

Biomarker / Dx

Epi / Nat. History

7 additional grants classified as “Other” (multi-disciplinary, infrastructure, etc.).

Funding by Fiscal Year

NIH fiscal year (Oct–Sep)

$45.7M

FY22

$33.8M

FY23

$53.2M

FY24

$56.3M

FY25

$7.0M

FY26

By Funding Mechanism

R01

115

R21

F31

R03

F32

K99

Funding Gap Analysis

Cross-referencing NIH grants against published research and clinical trials to identify funding-evidence gaps for Spinal Cord Injury. Strongest funded area: Basic Science. Largest gap: Biomarker / Diagnostics.

Biomarker / DiagnosticsFunded, Few Publications

9 funded grants in Biomarker / Diagnostics but only 0 related publications found for spinal cord injury. This may indicate early-stage research that hasn't yet produced published results.

Basic Science(107)

Basic ScienceR01Active

Microglial regulation of intermittent hypoxia induced phrenic motor plasticity

Mitchell, Gordon·UNIVERSITY OF FLORIDA·GAINESVILLE, FL

$1,522,569 (FY2025)

Spinal Cord Injury — NIH Grants & Funding

Funding Landscape

By Research Theme

Funding by Fiscal Year

By Funding Mechanism

Funding Gap Analysis

Basic Science(107)

Microglial regulation of intermittent hypoxia induced phrenic motor plasticity

Response-contingent learning to modulate synaptic plasticity for spinal cord injury

Multicellular Mechanisms Driving Axon Regeneration

Enhancing Respiratory Motor Function after Spinal Cord Injury

The Function and Mechanisms of Autophagy in Spinal Cord Injury

Spinal Cord Associative Plasticity

The Primate Corticospinal Connectome and Transcriptome

Efficient Delivery of Optimized Painless Nerve Growth Factors to the Central Nervous System to Treat Spinal Cord Injuries

Molecular Mechanisms of Oligodendrocyte Myelination and remyelination

From Neural Control of Movement to Treatments for Spinal Cord Injury

Translational(25)

Preclinical Toxicology Study of Intrathecal VersaMab-101 for spinal cord injury treatment

Enhancing Sympathetic Outflow Control Following Spinal Cord Injury Using Targeted Plasticity Therapy

Rapid In Vivo Screening of Combination Gene Therapies for Axonal Regeneration after Spinal Cord Injury

Does Electrical Stimulation Enhance the Capacity of Neural Stem Cell Transplants to Improve Recovery from Chronic Spinal Cord Injury

Treating Spinal Cord Injury with Mineral Coated Microparticles Releasing Anti-Inflammatory Cytokines

Targeting urinary tract dysfunctions after spinal cord injury with epidural stimulation

Regulation of nociceptor excitability by macrophage migration inhibitory factor (MIF) as a therapeutic strategy for chronic pain treatment after spinal cord injury

Stimulation-based strategies for forming new lesion-bridging circuitry and optimizing functional recovery after spinal cord injury

Harnessing engineered drug-free polymeric nanoformulations to reprogram innate immune cells for spinal trauma

Developing a kinase inhibitor drug to treat spinal cord injury

Clinical(43)

Inter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals with Acute Spinal Cord Injury

Paired Stimulation Plasticity for Motor Recovery

Stimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.

Epidural spinal cord stimulation and respiratory motor function after injury

Glycemic and Weight Loss Effects of Semaglutide in Subjects After Spinal Cord Injury and Type 2 Diabetes

Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

A Double-Blind, Randomized, Controlled Trial of Epidural Conus Medullaris Stimulation to Alleviate Pain and Augment Rehabilitation in Patients with Subacute Thoracic Spinal Cord Injury (SCI)

Normobaric Oxygen Therapy for Spinal Cord Injury

Spatiotemporal control of transcutaneous spinal cord stimulation for motor function in SCI

Protecting Endogenous Recovery from the "Infectious Insult" in Spinal Cord Injury

Epi / Nat. History(2)

Spinal cord injury causes liver pathology and metabolic dysfunction

Reducing Infection Susceptibility by Immune Function Restoration in Spinal Cord Injury

Gene/Cell Therapy(13)

Embryonic Stem Cell Therapy after Cervical Contusion SCI in NHPs

Mechanisms and therapeutic potential of phrenic proprioceptors after spinal cord injury

Promoting tissue repair and functional recovery after spinal cord injury by targeting the microtubule regulatory protein Fidgetin-like 2.

Regulated PTEN expression to overcome barriers to corticospinal tract regeneration after spinal cord injury

Injectable Hybrid SMART Spheroids to Enhance Stem Cell Therapy for CNS Injuries

MicroRNA Function During Neuronal Reprogramming in Treating Spinal Cord Injury

Magnetically Triggered Protein Release for Varying Severities of Spinal Cord Injury

Trehalose-based coacervates for biomolecular and cellular delivery to improve wound healing in spinal cord injury

FL2 siRNA as a Novel Therapeutic Option to Induce Spinal Cord Regeneration Following Injury

A novel adult neurons screening technology to repurpose FDA-approved drugs for spinal cord injury

Biomarker / Dx(9)

Discovery of Biomarker Signatures Prognostic for Neuropathic Pain after Acute Spinal Cord Injury

SV2A PET in Spinal Cord Injury Imaging

Neuroimaging and Connectome Analysis as a Diagnostic and Prognostic Biomarker of SCI Induced Neuropathic Pain

Identifying predictive biomarkers for acute intermittent hypoxia induced motor recovery in persons with incomplete spinal cord injury

CSF 5-HIAA detects secondary hypoxic insults in humans with traumatic spinal cord injuries

Prediction of Shoulder Injury for Disease Prevention in Children and Adults with Spinal Cord Injury Using Advanced Biomechanical Modeling and Diagnostic Imaging

Reprogramming reactive glial cells into functional new neurons after SCI

Cerebral spinal fluid serotonin and adenosine levels detect secondary injuries in traumatic spinal cord injury patients

Multi-parametric MRI and PET imaging of rat spinal cord injury

Medical Device(12)

An innovative device for management of neuropathic pain after spinal cord injury

Enhancing recovery of lower limb function after spinal cord injury

Spinal Reflex Conditioning System for Enhancing Motor Function Recovery After Incomplete Spinal Cord Injury

Non-invasive infrared light therapy and medical device to treat spinal cord injury

Calibrating Transcutaneous Spinal Stimulation for Spasticity, Pain, and Motor Function in SCI

Wireless, Closed?loop System to Restore Urological Dysfunction after Spinal Cord Injury

Modeling and safety of magnetic spinal cord stimulation

AccelBand, a leg-worn transcutaneous neuromodulation device for treating neurogenic bowel dysfunction in individuals with spinal cord injury

Augmenting Implanted Neuroprosthetics with Targeted Health Monitoring for Spinal Cord Injury - the LIFELINE

Spinal Cord Stimulation: A Novel Method to Restore Breathing in Spinal Cord Injury

Other(7)

Development of Nogo Receptor Decoy for the Treatment of Spinal Cord Injury

Targeting Cell-Type Specific Disease Phenotypes to Promote CNS Repair

Overcoming Neurogenic “Meta-Inflammation” to Promote Recovery After Spinal Cord Injury

Reducing adipose tissue dysfunction and metabolic complications by manipulating sensory processing after spinal cord injury

The role of macrophage metabolism and age in recovery from spinal cord injury