Dent disease

Dent disease is a rare genetic kidney condition that affects the renal tubules, the tiny tubes in the kidneys that help remove waste and extra water from the body. Specifically, it is characterized by problems in the proximal tubule, which is the first segment of the kidney tubule system. This dysfunction can impact the kidney’s ability to reabsorb important substances that the body needs, and may be associated with a range of kidney-related findings. The condition is known by several names, including Dent syndrome and Dent's disease, among others. Although the core issue is a problem in the kidney’s tubules, the exact features and severity may vary among people with the condition. The understanding of Dent disease continues to evolve as research on rare renal tubular disorders progresses.

Information about symptoms is currently limited for this condition.

Dent disease is a genetic disorder, meaning it is caused by changes in a gene that affect the kidney’s proximal tubule function. The condition is inherited, and it is known to follow an X-linked pattern in some of its forms, as suggested by its synonyms. This genetic link indicates that specific mutations disrupt the normal processing in the kidney, leading to the range of issues seen in this disorder.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about research is currently limited for this condition.