AA amyloidosis

AA amyloidosis, also known as secondary, inflammatory, reactive, or secondary amyloidosis, is a condition that happens as a complication of chronic inflammatory disorders such as rheumatoid arthritis. It occurs when a protein called serum amyloid A, which is normally present as part of the body’s response to inflammation, builds up and forms clumps called amyloid fibrils in different organs. These protein deposits most commonly affect the kidneys, but they can also be found in the spleen, suprarenal gland, liver, and gut. The buildup of amyloid fibrils disrupts the normal function of these organs, with kidney involvement being particularly prominent in this condition.

People with AA amyloidosis may experience symptoms related to kidney problems, as the condition mainly impacts the kidneys. Other organs such as the liver, spleen, adrenal glands, and gut can be involved, but detailed common signs and symptoms are not explicitly provided in the available information.

AA amyloidosis is caused by a long-lasting inflammatory process. It most often develops in the setting of chronic inflammatory disorders, especially rheumatoid arthritis. The inflammation leads to increased levels of serum amyloid A protein, which can aggregate into amyloid fibrils and deposit in various organs.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.