Overview

Limited structured data is available for this condition. Information continues to be gathered as research progresses.(5 data sources · Data coverage: Moderate)

Overview

Wolfram syndrome, also known as DIDMOAD, is a neurodegenerative disorder that commonly presents with a combination of type I diabetes mellitus, diabetes insipidus, sensorineural deafness, and bilateral optic atrophy. People with this condition may also experience a range of neurological symptoms along with additional issues such as urinary tract atony, ataxia, peripheral neuropathy, psychiatric disorders, and seizures. There are two types of Wolfram syndrome, referred to as type 1 (WS1) and type 2 (WS2), both of which share overlapping features. This summary is based on the information provided by trusted sources and helps to give an overview of the condition for educational purposes.

Symptoms & Signs

Common features seen in Wolfram syndrome include type I diabetes mellitus, diabetes insipidus, sensorineural deafness, and optic atrophy. Other symptoms may include neurological problems such as ataxia, seizure activity, urinary tract issues, peripheral neuropathy, and psychiatric challenges. These symptoms can vary in presence and severity among affected individuals.

Causes & Risk Factors

Information about causes is currently limited for this condition.

Treatment & Management

Information about treatment is currently limited for this condition.

Prognosis & Outlook

Information about prognosis is currently limited for this condition.

Research & Clinical Trials

Information about research is currently limited for this condition.

Patient Organizations

Connect with organizations supporting the Wolfram syndrome community

Wolfram Syndrome UK

Quick Resources

Helpful links for rare disease information and support

GARD (Genetic and Rare Diseases Information Center)NORD (National Organization for Rare Disorders)Find a Genetic Counselor

General Questions to Consider

Questions that may be helpful when speaking with your healthcare team

•Are there specialists or centers of excellence with experience in this condition?
•Is there a patient registry I could participate in?
•Should my family members consider genetic testing?
•What clinical trials might be available for this condition?
•Are there patient advocacy groups I should connect with?

Clinical

Associated Genes

2 genes

CISD2 WFS1

Gene data from HGNC • Click to view on NCBI Gene

Treatment

Support

Patient Advocacy Groups

View all PAGs →

W