GCGR-related hyperglucagonemia

GCGR-related hyperglucagonemia is a rare condition affecting the pancreas. It is caused by mutations in the GCGR gene and is characterized by an overgrowth of pancreatic alpha cells (alpha cell hyperplasia) and the development of pancreatic neuroendocrine tumors. Despite the markedly high levels of serum glucagon, people with this condition do not show the classic signs of a glucagonoma syndrome. People with this condition may experience a variety of symptoms including abdominal pain and symptoms related to pancreatic inflammation. The condition results from an abnormal genetic change that alters the function of pancreatic cells, leading to an imbalance in hormone levels.

Common symptoms may include abdominal pain, pancreatitis, fatigue, diarrhea, and diabetes mellitus. These symptoms can vary among people with this condition.

This condition is caused by mutations in the GCGR gene. The genetic change leads to abnormal growth of the pancreatic alpha cells, which produce the hormone glucagon. Such genetic factors play a key role in the development of the condition.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research is currently limited for this condition.