A seizure disorder characterized by intermittent dystonia and/or choreoathetoid movements that occur during sleep. The clusters of nocturnal motor seizures are often stereotyped and brief.
Comprehensive, easy-to-understand information about this condition
How we create this content →Documentation on autosomal dominant nocturnal frontal lobe epilepsy is limited due to its rarity and the absence of a clearly defined genetic basis. The condition affects a small number of individuals, resulting in fewer systematic clinical studies. Additionally, the phenotypic variability and overlap with other seizure disorders contribute to the challenges in understanding and documenting this condition thoroughly. Ongoing research may help clarify these aspects in the future.
The clinical picture of ADNFLE includes a range of symptoms primarily occurring during sleep. The most common symptom is nocturnal seizures, experienced by 80-99% of patients. Other notable features include motor stereotypy (30-79%) and paroxysmal dystonia (30-79%). Additional symptoms may include involuntary movements, urinary incontinence, and psychological symptoms such as depression and anxiety, each affecting 5-29% of individuals. This variability in symptoms can make diagnosis challenging.
To navigate your journey with autosomal dominant nocturnal frontal lobe epilepsy, consider consulting a neurologist with expertise in epilepsy disorders, particularly those specializing in nocturnal seizures. While there are currently no identified patient organizations or clinical trials, you can explore resources like the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov for additional information and support. Engaging with a genetic counselor may also be beneficial, especially if any genetic basis is suspected in your family.
Actionable guidance for navigating care for autosomal dominant nocturnal frontal lobe epilepsy
To navigate your journey with autosomal dominant nocturnal frontal lobe epilepsy, consider consulting a neurologist with expertise in epilepsy disorders, particularly those specializing in nocturnal seizures. While there are currently no identified patient organizations or clinical trials, you can explore resources like the Genetic and Rare Diseases Information Center (GARD) at rarediseases.info.nih.gov for additional information and support. Engaging with a genetic counselor may also be beneficial, especially if any genetic basis is suspected in your family.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 6, 2026
Consider asking your healthcare providers these condition-specific questions
European rare disease database
Genetic and Rare Diseases Info Center
AI-Generated Content: This summary was generated using AI. Always consult with qualified healthcare providers for medical guidance.
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