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Acquired angioedema (AAE) is characterized by the occurrence of transitory and recurrent subcutaneous and/or submucosal edemas resulting in swelling and/or abdominal pain due to an acquired C1 inhibitor (C1-INH) deficiency.
Biomarker and diagnostic research for acquired angioedema has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
3 clinical trials registered, 3 recruiting. Interventions under study include drug therapy, other interventions, and biologic therapy. Pipeline includes 1 PHASE4, 1 PHASE3. Research is sponsored by a mix of industry and academic institutions.
49 publications have been identified in PubMed for acquired angioedema. Research spans Case Report / Case Series (49%), Epidemiology / Natural History (18%), and Review / Meta-Analysis (12%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 24 |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 3:00 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about acquired angioedema
Disease patterns and progression | 9 | 18% |
Research summaries | 6 | 12% |
Testing and diagnosis research | 3 | 6% |
Clinical study results | 3 | 6% |
Laboratory research | 3 | 6% |
Other research | 1 | 2% |
Palestra F (2026). [PMID: 41784098](https://pubmed.ncbi.nlm.nih.gov/41784098/). *J Investig Allergol Clin Immunol*. [Basic Science / Preclinical]
Poznańska-Kurowska K (2026). [PMID: 42194761](https://pubmed.ncbi.nlm.nih.gov/42194761/). *J Clin Med*. [Review / Meta-Analysis]
Habibi S (2026). [PMID: 37069828](https://pubmed.ncbi.nlm.nih.gov/37069828/). *J Oncol Pharm Pract*. [Case Report / Case Series]
Tarsitano M (2026). [PMID: 41752838](https://pubmed.ncbi.nlm.nih.gov/41752838/). *Life (Basel)*. [Basic Science / Preclinical]
Shiota S (2026). [PMID: 42038954](https://pubmed.ncbi.nlm.nih.gov/42038954/). *J Gen Fam Med*. [Case Report / Case Series]
Bhattarai I (2026). [PMID: 41588789](https://pubmed.ncbi.nlm.nih.gov/41588789/). *Int J Rheum Dis*. [Other]
de Lange M (2026). [PMID: 42220494](https://pubmed.ncbi.nlm.nih.gov/42220494/). *Front Immunol*. [Case Report / Case Series]
Çildağ S (2026). [PMID: 41867000](https://pubmed.ncbi.nlm.nih.gov/41867000/). *Turk J Haematol*. [Case Report / Case Series]
de Jong GM (2026). [PMID: 41670049](https://pubmed.ncbi.nlm.nih.gov/41670049/). *J Investig Allergol Clin Immunol*. [Case Report / Case Series]
Habib R (2026). [PMID: 42113672](https://pubmed.ncbi.nlm.nih.gov/42113672/). *J Investig Med High Impact Case Rep*. [Case Report / Case Series]