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Acral persistent papular mucinosis is a rare chronic form of localized lichen myxedematosus characterized by the development of multiple symmetrical skin-colored mucinous papules exclusively on the extensor surface of the hands and distal forearms.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for acral persistent papular mucinosis.
6 publications have been identified in PubMed for acral persistent papular mucinosis. Research spans Case Report / Case Series (50%), Review / Meta-Analysis (33%), and Other (17%).
Aparício Martins A (2026). [PMID: 41814924](https://pubmed.ncbi.nlm.nih.gov/41814924/). *J Dtsch Dermatol Ges*. [Case Report / Case Series]
Go K (2026). [PMID: 42129965](https://pubmed.ncbi.nlm.nih.gov/42129965/). *J Dermatol*. [Other]
Miller D (2025). [PMID: 40957063](https://pubmed.ncbi.nlm.nih.gov/40957063/). *JMIR Dermatol*. [Review / Meta-Analysis]
Ma X (2025). [PMID: 39755424](https://pubmed.ncbi.nlm.nih.gov/39755424/). *Mayo Clin Proc*. [Review / Meta-Analysis]
Öner S (2025). [PMID: 41235088](https://pubmed.ncbi.nlm.nih.gov/41235088/). *JAAD Case Rep*. [Case Report / Case Series]
Ding MY (2024). [PMID: 38984022](https://pubmed.ncbi.nlm.nih.gov/38984022/). *Transl Pediatr*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 3:20 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about acral persistent papular mucinosis