acroosteolysis-keloid-like lesions-premature aging syndrome

Acroosteolysis-keloid-like lesions-premature aging syndrome is a rare condition that has been reported under several names, including premature ageing syndrome, Penttinen type, and progeroid syndrome. Although a detailed definition is not available, the name of the condition suggests that people with this disorder may experience early signs of aging along with skin and bone changes. The condition has been associated with abnormalities in the PDGFRB gene, which may play a role in its development. Several identifiers, such as OMIM:601812, Orphanet:363665, and GARD:4276, help researchers and clinicians to recognize and further study this rare disease.

The name of the condition provides some clues about its features. The terms acroosteolysis, keloid-like lesions, brachydactyly, and delayed bone maturation suggest that people with this condition might experience bone loss in the fingers or toes, raised scar-like skin lesions, short fingers, and slower development of bones. However, detailed information on the range and frequency of symptoms is limited.

Research indicates that changes in the PDGFRB gene are linked to acroosteolysis-keloid-like lesions-premature aging syndrome. This genetic association suggests that variations in this gene may cause the disorder. Additional details about other contributing factors or risk factors are not available.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.