Rapid deterioration of liver function causing encephalopathy and coagulopathy. It results from damage to the liver parenchyma usually secondary to acetaminophen overdose or viral infections.
Comprehensive, easy-to-understand information about this condition
How we create this content →Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 30, 2026
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 30, 2026
The limited documentation regarding acute liver failure is primarily due to its rarity, affecting fewer than 1 in 10,000 individuals. This rarity restricts the scope of systematic clinical studies and comprehensive phenotype documentation. Furthermore, the genetic basis is still being explored, which adds to the challenges in understanding the full clinical picture.
To navigate your care for acute liver failure, consider consulting a hepatologist or a gastroenterologist with expertise in liver diseases. They can provide specialized insight into your condition and potential treatment options. Additionally, you may look into participating in clinical trials, which can be found at ClinicalTrials.gov. Although there are currently no patient organizations identified for this condition, resources like GARD (rarediseases.info.nih.gov) may offer valuable information and support.
There are several orphan drugs in development for acute liver failure, including a bioartificial liver system using encapsulated human Hep G2 cells, cardiotrophin-1, and N-acetylcysteine. Currently, there are 79 active clinical trials exploring various treatment options and interventions. For more information, you can search the active trials at ClinicalTrials.gov: https://clinicaltrials.gov/search?cond=acute%20liver%20failure.
Actionable guidance for navigating care for acute liver failure
To navigate your care for acute liver failure, consider consulting a hepatologist or a gastroenterologist with expertise in liver diseases. They can provide specialized insight into your condition and potential treatment options. Additionally, you may look into participating in clinical trials, which can be found at ClinicalTrials.gov. Although there are currently no patient organizations identified for this condition, resources like GARD (rarediseases.info.nih.gov) may offer valuable information and support.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 30, 2026
Consider asking your healthcare providers these condition-specific questions
European rare disease database
Genetic and Rare Diseases Info Center
AI-Generated Content: This summary was generated using AI. Content has been fact-checked. Always consult with qualified healthcare providers for medical guidance.
Organizations with approved therapies for this disease
No approved therapies yet
Research is ongoing — 8 companies have orphan drug designations for this disease
Kisho delivers this disease record via API, including phenotypes (HPO), genes, orphan drug designations, screening status, and PAG mapping, with version history and governance.
AI-curated news mentioning acute liver failure
Updated Feb 2, 2026
A case report details the diagnosis of intra-abdominal mucormycosis during liver transplantation for acute liver failure. This finding highlights the need for awareness of opportunistic infections in patients undergoing major surgeries.