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An acute myeloid leukemia (AML) in which the blasts do not show evidence of myeloid differentiation by morphology and conventional cytochemistry. (WHO, 2001)
Biomarker and diagnostic research for acute myeloid leukemia with minimal differentiation has been reported in the published literature.
8 clinical trials registered, 3 recruiting. Interventions under study include other interventions, drug therapy, and gene therapy. Pipeline includes 1 PHASE4, 1 PHASE1, 3 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07250217](https://clinicaltrials.gov/study/NCT07250217) | Determination of Epigenetic Markers of Acute Myeloblastic Leukemia in Elderly Patients | NA | Groupe Hospitalier de la Region de Mulhouse et Sud Alsace | UNKNOWN |
[NCT07016165](https://clinicaltrials.gov/study/NCT07016165) | Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in Children With Hematologic Malignancies | PHASE4 | Gadjah Mada University | RECRUITING |
[NCT05558943](https://clinicaltrials.gov/study/NCT05558943) | Study of Management and Prognosis of Patients With Acute Myeloblastic Leukemia in Saint-Antoine Hospital | — | Assistance Publique - Hôpitaux de Paris | NOT_YET_RECRUITING |
[NCT07060612](https://clinicaltrials.gov/study/NCT07060612) | Incidence and Risk Factors for the Development of Invasive Fungal Infection in Patients Diagnosed With Acute Myeloblastic Leukemia (HIFA) | — | Instituto de Investigacion Sanitaria La Fe | UNKNOWN |
[NCT00898456](https://clinicaltrials.gov/study/NCT00898456) | Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia | — | Alliance for Clinical Trials in Oncology | UNKNOWN |
28 publications have been identified in PubMed for acute myeloid leukemia with minimal differentiation. Research spans Basic Science / Preclinical (36%), Gene Therapy / Novel Therapeutics (18%), and Case Report / Case Series (14%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 10 | 36% |
New treatment approaches | 5 | 18% |
Patient case studies | 4 | 14% |
Clinical study results | 3 | 11% |
Disease patterns and progression | 3 | 11% |
Testing and diagnosis research | 2 |
Smetana K (2026). [PMID: 41980000](https://pubmed.ncbi.nlm.nih.gov/41980000/). *Folia Biol (Praha)*. [Other]
Kamitori T (2026). [PMID: 42056531](https://pubmed.ncbi.nlm.nih.gov/42056531/). *Leukemia*. [Basic Science / Preclinical]
Wei Q (2026). [PMID: 41262054](https://pubmed.ncbi.nlm.nih.gov/41262054/). *Haematologica*. [Case Report / Case Series]
Hervet P (2026). [PMID: 41117492](https://pubmed.ncbi.nlm.nih.gov/41117492/). *Cytopathology : official journal of the British Society for Clinical Cytology*. [Case Report / Case Series]
Qiu R (2026). [PMID: 41915675](https://pubmed.ncbi.nlm.nih.gov/41915675/). *PLoS One*. [Basic Science / Preclinical]
Komori T (2026). [PMID: 41631723](https://pubmed.ncbi.nlm.nih.gov/41631723/). *British journal of haematology*. [Gene Therapy / Novel Therapeutics]
Anvari S (2026). [PMID: 42135452](https://pubmed.ncbi.nlm.nih.gov/42135452/). *Sci Rep*. [Gene Therapy / Novel Therapeutics]
Eser A (2025). [PMID: 40214058](https://pubmed.ncbi.nlm.nih.gov/40214058/). *Nigerian journal of clinical practice*. [Clinical Trial Publication]
Obakachi VA (2025). [PMID: 40979648](https://pubmed.ncbi.nlm.nih.gov/40979648/). *In silico pharmacology*. [Basic Science / Preclinical]
Zhang R (2025). [PMID: 40214882](https://pubmed.ncbi.nlm.nih.gov/40214882/). *Blood research*. [Basic Science / Preclinical]
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 9:41 PM UTC
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European rare disease database
Genetic and Rare Diseases Info Center
Other research | 1 | 4% |