Adrenomyodystrophy is an extremely rare genetic endocrine disease. It is marked by a range of serious symptoms including primary adrenal insufficiency and dystrophic myopathy. This condition also involves liver issues such as hepatic steatosis and eye problems like megalocornea. In addition, individuals with this condition may experience severe psychomotor delay, failure to thrive, chronic constipation, and terminal bladder ectasia, which can lead to death. The medical literature on adrenomyodystrophy is limited with the last detailed description published in 1982.

People with adrenomyodystrophy may experience a number of symptoms. These include primary adrenal insufficiency, muscle weakness due to dystrophic myopathy, and liver problems such as hepatic steatosis. They may also have severe delays in psychomotor development, abnormally large eyes (megalocornea), failure to thrive, chronic constipation, and issues with the bladder (terminal bladder ectasia).

Adrenomyodystrophy is described as a genetic endocrine disorder. Information regarding the specific genetic causes or risk factors is limited since there are no known genes currently attributed to this condition.