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An acute lymphoblastic leukemia occurring during adulthood.
Biomarker and diagnostic research for adult acute lymphoblastic leukemia has been reported in the published literature.
No approved treatments are currently available for adult acute lymphoblastic leukemia. An additional 10 compounds hold orphan drug designation.
While no drugs are FDA-approved specifically for adult acute lymphoblastic leukemia, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.
The following drugs have received orphan drug designation from the FDA for adult acute lymphoblastic leukemia. Orphan designation reflects regulatory interest and does not indicate approval for treatment.
Brand Name | Generic Name | Sponsor |
|---|
31 clinical trials registered, 8 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 8 PHASE2, 9 PHASE1, 4 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT02872987](https://clinicaltrials.gov/study/NCT02872987) |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:58 PM UTC
Program availability and eligibility requirements are set by each foundation. Contact them directly to learn more about your options.
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Designated
Exclusivity End |
|---|
Designation Status |
|---|
small molecule cytidine triphosphate synthase 1 (CTPS1) inhibitor | small molecule cytidine triphosphate synthase 1 (CTPS1) inhibitor | Step Pharma | 2025 | — | Designated |
Lusvertikimab | Lusvertikimab | OSE Immunotherapeutics | 2023 | — | Designated |
Therapeutic Inducers of Natural Killer cell Killing Immunotherapy expanded from cord blood-derived hematopoietic progenitors | Therapeutic Inducers of Natural Killer cell Killing Immunotherapy expanded from cord blood-derived hematopoietic progenitors | Centre Hospitalier Universitaire Sainte-Justine | 2023 | — | Designated |
dasatinib | dasatinib | Xspray Pharma AB | 2022 | — | Designated |
6-(4-(tert-butyl)phenoxy)pyridin-3-amine hydrochloride | 6-(4-(tert-butyl)phenoxy)pyridin-3-amine hydrochloride | Cellestia Biotech AG | 2022 | — | Designated |
Anti-CD19 Chimeric Antigen Receptor T-Cell Injection | Anti-CD19 Chimeric Antigen Receptor T-Cell Injection | Juventas Cell Therapy Ltd. | 2022 | — | Designated |
allogeneic anti-CD19 chimeric antigen receptor (CAR)-T cells | allogeneic anti-CD19 chimeric antigen receptor (CAR)-T cells | Imugene Limited | 2018 | — | Designated |
granaticin B | granaticin B | Lin BioScience | 2018 | — | Designated |
Autologous CD3+ T cells transduced with retroviral vector containing a chimeric antigen receptor directed against CD19 (Autologous CD3+ T cells containing CD19 chimeric antigen receptor) | Autologous CD3+ T cells transduced with retroviral vector containing a chimeric antigen receptor directed against CD19 (Autologous CD3+ T cells containing CD19 chimeric antigen receptor) | Juno Therapeutics, Inc. | 2014 | — | Withdrawn |
small molecule inhibitor of histone methyltransferase DOT1L | small molecule inhibitor of histone methyltransferase DOT1L | Epizyme Inc. | 2013 | — | Designated |
Gene therapy approaches for adult acute lymphoblastic leukemia have been reported in the published literature.
31 trials found
GMALL Registry and Collection of Biomaterial: Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult Acute Lymphoblastic Leukemia (ALL) Patients and Related Diseases Associated With a Prospective Collection of Biomaterial |
— |
Goethe University |
RECRUITING |
[NCT06727942](https://clinicaltrials.gov/study/NCT06727942) | Virtual Reality-Infused Treadmill Training on Aging-Related Outcomes | NA | The University of Texas at Arlington | RECRUITING |
[NCT01137643](https://clinicaltrials.gov/study/NCT01137643) | Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer | — | UNC Lineberger Comprehensive Cancer Center | RECRUITING |
[NCT02727803](https://clinicaltrials.gov/study/NCT02727803) | Personalized NK Cell Therapy in CBT | PHASE2 | M.D. Anderson Cancer Center | RECRUITING |
[NCT01137825](https://clinicaltrials.gov/study/NCT01137825) | Registry of Older Patients With Cancer | — | UNC Lineberger Comprehensive Cancer Center | RECRUITING |
320 publications have been identified in PubMed for adult acute lymphoblastic leukemia. Research spans Review / Meta-Analysis (35%), Epidemiology / Natural History (18%), and Basic Science / Preclinical (15%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 98 | 35% |
Disease patterns and progression | 50 | 18% |
Laboratory research | 42 | 15% |
Clinical study results | 41 | 15% |
Patient case studies | 20 | 7% |
Testing and diagnosis research | 14 | 5% |
New treatment approaches | 9 | 3% |
Other research | 4 | 1% |
Phuong LK (2026). [PMID: 41786472](https://pubmed.ncbi.nlm.nih.gov/41786472/). *Arch Dis Child*. [Epidemiology / Natural History]
Eriksen JVN (2026). [PMID: 41733102](https://pubmed.ncbi.nlm.nih.gov/41733102/). *Br J Haematol*. [Diagnostic / Biomarker]
Krishnan S (2026). [PMID: 40695248](https://pubmed.ncbi.nlm.nih.gov/40695248/). *Acta haematologica*. [Review / Meta-Analysis]
Muffly L (2026). [PMID: 42154904](https://pubmed.ncbi.nlm.nih.gov/42154904/). *Blood*. [Review / Meta-Analysis]
Arnaud I (2026). [PMID: 41404764](https://pubmed.ncbi.nlm.nih.gov/41404764/). *Leukemia & lymphoma*. [Epidemiology / Natural History]
Shanmuganathan N (2026). [PMID: 39289867](https://pubmed.ncbi.nlm.nih.gov/39289867/). *Br J Haematol*. [Review / Meta-Analysis]
Othman T (2026). [PMID: 42150924](https://pubmed.ncbi.nlm.nih.gov/42150924/). *Clin Lymphoma Myeloma Leuk*. [Review / Meta-Analysis]
Wang W (2026). [PMID: 41852325](https://pubmed.ncbi.nlm.nih.gov/41852325/). *Haematologica*. [Basic Science / Preclinical]
Soetadji RS (2026). [PMID: 42199526](https://pubmed.ncbi.nlm.nih.gov/42199526/). *Biomed Rep*. [Review / Meta-Analysis]
Lehr J (2026). [PMID: 40749817](https://pubmed.ncbi.nlm.nih.gov/40749817/). *Clin Chim Acta*. [Review / Meta-Analysis]