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African iron overload - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

African iron overload

MONDO:0011012

Also known as:Bantu siderosisiron overload in Africahereditary iron overload and African Americans

Overview

African iron overload is a rare disorder described in sub-Saharan African populations and is characterized by iron overload due to excess dietary iron intake and possibly genetic factors, leading to hepatic portal fibrosis and micronodular cirrhosis.

GeneticsAutosomal dominant

Patient Orgs1 organizations · African Americans with Ataxia Association

ResearchLimited published research (1 article)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Elevated ferritin (iron storage marker) (increased circulating ferritin concentration); and common findings: Elevated transferrin saturation, Liver scarring (fibrosis) (hepatic fibrosis), Hepatic periportal necrosis, and Viral hepatitis and others. 26 total HPO annotations.

Organ System	Phenotype Count	Example Features
Digestive system	11	Liver scarring (fibrosis) (hepatic fibrosis), Hepatic periportal necrosis, Viral hepatitis

Prognosis

Phenotype severity distribution: 1 very common feature, 6 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for African iron overload.

1 publication has been identified in PubMed for African iron overload. Research spans Epidemiology / Natural History (100%).

Recent Publications

Conway RB (2024). [PMID: 39678225](https://pubmed.ncbi.nlm.nih.gov/39678225/). *Diabetes, metabolic syndrome and obesity : targets and therapy*. [Epidemiology / Natural History]

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 11:11 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Patient Advocacy Groups

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African Americans with Ataxia AssociationPrimary Focus

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Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.

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Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:601195

Orphanet

European rare disease database

Orphanet:139507

GARD

Genetic and Rare Diseases Info Center

GARD:8495

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→How can I connect with African Americans with Ataxia Association and other patient organizations for support?

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African iron overload

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Patient Support

Patient Advocacy Groups

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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