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amniotic band syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

amniotic band syndrome

MONDO:0015167

Also known as:Adam syndromeStreeter dysplasiaamniotic band constriction

Find Clinical TrialsTrials

Overview

A group of sporadic congenital anomalies, that occur in association with amniotic bands, involving the limbs, craniofacial regions, spine and trunk with a highly variable clinical spectrum ranging from simple digital band constriction (or amputation) to complex craniofacial, central nervous system and visceral anomalies.

GeneticsSporadic (not inherited)

Clinical Trials2 registered

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Ectopia cordis, Cleft palate, Talipes equinovarus, and Sideways curvature of the spine (scoliosis) and 11 more.

Organ System	Phenotype Count	Example Features
Head and neck	3	Cleft palate, Cleft upper lip, Tessier cleft
Bones and joints

Diagnosis

Biomarker and diagnostic research for amniotic band syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered. Interventions under study include medical devices and other interventions. Pipeline includes 2 NA. Research is primarily sponsored by academic and government institutions.

40 publications have been identified in PubMed for amniotic band syndrome. Research spans Case Report / Case Series (60%), Review / Meta-Analysis (18%), and Epidemiology / Natural History (8%).

Research Type	Count	% of Total
Patient case studies	24

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 11:55 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:217100

Orphanet

European rare disease database

Orphanet:1034 Orphanet:295000

GARD

Genetic and Rare Diseases Info Center

GARD:429

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

amniotic band syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

amniotic band syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications