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amyotrophic lateral sclerosis type 9 (ALS9) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

amyotrophic lateral sclerosis type 9

MONDO:0012753

Also known as:ALS9ANG amyotrophic lateral sclerosisamyotrophic lateral sclerosis 9

Overview

Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the ANG gene.

GeneticsAutosomal dominant · ANG (chr 14)

Clinical Presentation

Features include: Distal amyotrophy, Distal muscle weakness, Amyotrophic lateral sclerosis, and Spasticity.

Organ System	Phenotype Count	Example Features
Muscles	1	Distal muscle weakness
Brain and nerves	1	Spasticity

Explore clinical features

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

ANG encodes angiogenin (147 aa). Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context. Highest expression in Liver (726.8 TPM) and Ovary (91.1 TPM).

Amyotrophic lateral sclerosis type 9 has limited evidence linking it to mutations in the ANG gene on chromosome 14.

ANG is classified as a druggable target (Druggable Genome category) with score 7.5.

Diagnosis

Genetic testing for ANG is available. Testing is considered research-grade for diagnosis.

Biomarker and diagnostic research for amyotrophic lateral sclerosis type 9 has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for amyotrophic lateral sclerosis type 9.

179 publications have been identified in PubMed for amyotrophic lateral sclerosis type 9. Research spans Basic Science / Preclinical (25%), Epidemiology / Natural History (23%), and Review / Meta-Analysis (21%).

Research Type	Count	% of Total
Laboratory research	44	25%

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 6:54 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:611895

GARD

Genetic and Rare Diseases Info Center

GARD:10498

Questions for Your Care Team

→Should I pursue genetic testing for ANG, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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amyotrophic lateral sclerosis type 9

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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