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A WHO grade III meningioma characterized by the presence of malignant morphologic features, including malignant cytology and a very high mitotic index (20 or more mitoses per ten high power fields).
Biomarker and diagnostic research for anaplastic meningioma has been reported in the published literature.
9 clinical trials registered, 6 recruiting. Interventions under study include drug therapy, procedural interventions, biologic therapy, and other interventions. Pipeline includes 3 PHASE2, 1 PHASE1, 1 EARLY_PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT02847559](https://clinicaltrials.gov/study/NCT02847559) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 3:00 PM UTC
Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma |
PHASE2 |
Northwestern University |
UNKNOWN |
[NCT04501705](https://clinicaltrials.gov/study/NCT04501705) | Apatinib in the Treatment of Recurrent Atypical/malignant Meningioma in Adults | NA | Beijing Sanbo Brain Hospital | RECRUITING |
[NCT05793034](https://clinicaltrials.gov/study/NCT05793034) | Predictive Factors for Survival in Aggressive Meningiomas | NA | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | RECRUITING |
[NCT06275919](https://clinicaltrials.gov/study/NCT06275919) | Regorafenib for Recurrent Meningioma (MIRAGE Trial) | PHASE2 | Istituto Oncologico Veneto IRCCS | RECRUITING |
[NCT04541082](https://clinicaltrials.gov/study/NCT04541082) | Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms | PHASE1 | Jazz Pharmaceuticals | RECRUITING |
161 publications have been identified in PubMed for anaplastic meningioma. Research spans Review / Meta-Analysis (26%), Basic Science / Preclinical (21%), and Case Report / Case Series (20%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 41 | 26% |
Laboratory research | 34 | 21% |
Patient case studies | 32 | 20% |
Disease patterns and progression | 18 | 11% |
Testing and diagnosis research | 15 | 9% |
Clinical study results | 9 | 6% |
New treatment approaches | 6 | 4% |
Other research | 4 | 3% |
Noriega-Silva LA (2026). [PMID: 41774884](https://pubmed.ncbi.nlm.nih.gov/41774884/). *Rev Med Inst Mex Seguro Soc*. [Case Report / Case Series]
Toyoda N (2026). [PMID: 42286667](https://pubmed.ncbi.nlm.nih.gov/42286667/). *J Med Case Rep*. [Case Report / Case Series]
Welch RL (2026). [PMID: 41217766](https://pubmed.ncbi.nlm.nih.gov/41217766/). *J Neuropathol Exp Neurol*. [Case Report / Case Series]
Shibagaki K (2026). [PMID: 42232433](https://pubmed.ncbi.nlm.nih.gov/42232433/). *Surg Neurol Int*. [Case Report / Case Series]
Wei CZ (2026). [PMID: 40844288](https://pubmed.ncbi.nlm.nih.gov/40844288/). *Neurosurgery*. [Review / Meta-Analysis]
Sun Y (2026). [PMID: 42234071](https://pubmed.ncbi.nlm.nih.gov/42234071/). *Discov Oncol*. [Case Report / Case Series]
Ueta A (2026). [PMID: 41469137](https://pubmed.ncbi.nlm.nih.gov/41469137/). *Anticancer Res*. [Basic Science / Preclinical]
Rahmanzade R (2026). [PMID: 42034799](https://pubmed.ncbi.nlm.nih.gov/42034799/). *Acta Neuropathol*. [Basic Science / Preclinical]
Maier AD (2026). [PMID: 41486296](https://pubmed.ncbi.nlm.nih.gov/41486296/). *Acta Neuropathol Commun*. [Basic Science / Preclinical]
Aggarwal A (2026). [PMID: 41476144](https://pubmed.ncbi.nlm.nih.gov/41476144/). *Neuro Oncol*. [Basic Science / Preclinical]