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Annular epidermolytic ichthyosis (AEI) is a rare clinical variant of epidermolytic ichthyosis (EI) characterized by the presence of a blistering phenotype at birth and the development from early infancy of annular polycyclic erythematous scales on the trunk and extremities.
Biomarker and diagnostic research for annular epidermolytic ichthyosis has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for annular epidermolytic ichthyosis.
2 publications have been identified in PubMed for annular epidermolytic ichthyosis. Research spans Diagnostic / Biomarker (50%) and Case Report / Case Series (50%).
Süßmuth K (2026). [PMID: 41892076](https://pubmed.ncbi.nlm.nih.gov/41892076/). *Dermatopathology (Basel)*. [Diagnostic / Biomarker]
Smits E (2025). [PMID: 40741111](https://pubmed.ncbi.nlm.nih.gov/40741111/). *Clin Case Rep*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 11:12 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center