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anterior ischemic optic neuropathy - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

anterior ischemic optic neuropathy

MONDO:0006649

Also known as:ischaemic optic neuropathyischemic optic neuropathyaion

Find Clinical TrialsTrials

Overview

Anterior ischemic optic neuropathy (AION) is an eye disease characterized by infarction of the optic disk leading to vision loss. It can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or NAION) or arteritic, the latter being associated with giant cell arteritis (GCA; often termed temporal arteritis). Vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. Symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. At exam, visual acuity is reduced and the optic disk is swollen. In both subtypes, visual field examination is often reduced in the inferior and central visual fields. The visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. The arteritic variety is treated with corticosteroids. Treatment of the nonarteritic variety withaspirinor corticosteroids has not been helpful.

TreatmentsNo approved treatments · 4 in pipeline

Clinical Trials10 registered · 8 recruiting

Diagnosis

Biomarker and diagnostic research for anterior ischemic optic neuropathy has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for anterior ischemic optic neuropathy. An additional 4 compounds hold orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for anterior ischemic optic neuropathy, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for anterior ischemic optic neuropathy. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

10 clinical trials registered, 8 recruiting. Interventions under study include other interventions, drug therapy, medical devices, and gene therapy. Pipeline includes 1 PHASE4, 1 PHASE3, 2 PHASE1. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT03475173](https://clinicaltrials.gov/study/NCT03475173)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:45 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

GARD

Genetic and Rare Diseases Info Center

GARD:9790

Questions for Your Care Team

→Are any of the 10 active clinical trials a good fit for my situation?
→With 4 compounds in the orphan drug pipeline, which are furthest along in development and which clinical trials should I be aware of?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Disease patterns and progression	45	30%
Research summaries	43	29%
Other research	16	11%
Patient case studies	15	10%
Testing and diagnosis research	14	9%
Laboratory research	7	5%
Clinical study results	6	4%
New treatment approaches	2	1%

Kisho

anterior ischemic optic neuropathy

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

External Resources

GARD

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Wernicke encephalopathy presenting with severe optic neuropathy and oculomotor dysfunction.

Orbital MRI for diagnosing giant cell arteritis in cases of anterior ischaemic optic neuropathy.

anterior ischemic optic neuropathy

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

External Resources

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Wernicke encephalopathy presenting with severe optic neuropathy and oculomotor dysfunction.

Orbital MRI for diagnosing giant cell arteritis in cases of anterior ischaemic optic neuropathy.