Congenital narrowing of a segment of the aorta. Signs and symptoms include hypertension, muscle weakness, shortness of breath, headaches and leg cramps.
Comprehensive, easy-to-understand information about this condition
How we create this content →Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 31, 2026
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 31, 2026
Documentation on aorta coarctation may be limited due to its relatively rare occurrence and the multifactorial nature of its inheritance. As this condition affects fewer individuals, comprehensive clinical studies are less common, leading to gaps in understanding its full genetic basis and long-term outcomes. The variability in symptoms and severity among affected individuals further complicates the ability to establish standardized care protocols.
The clinical picture of aorta coarctation primarily involves cardiovascular symptoms. Hypertension is present in 5-29% of patients, while muscle weakness, shortness of breath, and headaches are also reported. In addition, structural heart abnormalities such as abnormal left ventricular outflow tract morphology (80-99%) and bicuspid aortic valve (30-79%) are common. Congestive heart failure and coronary artery atherosclerosis may occur in 5-29% of cases, indicating the potential severity of this condition.
To navigate aorta coarctation effectively, consider consulting with a cardiologist who specializes in congenital heart defects. They can provide tailored management strategies and monitor your condition closely. Additionally, genetic counseling may be beneficial, especially given the multifactorial inheritance pattern. For resources, the National Organization for Rare Disorders (NORD) offers information and support at rarediseases.org. While no patient organizations are currently identified, participating in clinical trials may also provide valuable insights and access to cutting-edge treatments.
Currently, there are 15 active clinical trials investigating various aspects of aorta coarctation. These trials may focus on innovative treatment approaches and management strategies. For more information on ongoing research, you can visit the ClinicalTrials.gov search page at https://clinicaltrials.gov/search?cond=aorta%20coarctation. While there are no orphan drugs designated for this condition, the active research landscape offers hope for advancements in understanding and treatment.
Actionable guidance for navigating care for aorta coarctation
To navigate aorta coarctation effectively, consider consulting with a cardiologist who specializes in congenital heart defects. They can provide tailored management strategies and monitor your condition closely. Additionally, genetic counseling may be beneficial, especially given the multifactorial inheritance pattern. For resources, the National Organization for Rare Disorders (NORD) offers information and support at rarediseases.org. While no patient organizations are currently identified, participating in clinical trials may also provide valuable insights and access to cutting-edge treatments.
Consider asking your healthcare providers these condition-specific questions
Helpful links for rare disease information and support
Inheritance patterns describe how genetic conditions are passed from parents to children.
Research studies investigating treatments and therapies for this condition.
Active Trials
Total Trials
Data from ClinicalTrials.gov Jan 31, 2026
Consider asking your healthcare providers these condition-specific questions
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
AI-Generated Content: This summary was generated using AI. Content has been fact-checked. Always consult with qualified healthcare providers for medical guidance.
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