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A carcinoma that arises from glandular epithelial cells of the vermiform appendix.
Biomarker and diagnostic research for appendix adenocarcinoma has been reported in the published literature.
6 clinical trials registered, 4 recruiting. Interventions under study include drug therapy, other interventions, gene therapy, and procedural interventions. Pipeline includes 1 PHASE2, 2 PHASE1, 1 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05947838](https://clinicaltrials.gov/study/NCT05947838) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 2:11 PM UTC
Genetic and Rare Diseases Info Center
A Prospective Feasibility Study Using ctDNA to Tailor Neoadjuvant Chemotherapy for Patients With Colorectal or Appendiceal Adenocarcinoma |
NA |
M.D. Anderson Cancer Center |
RECRUITING |
[NCT06207305](https://clinicaltrials.gov/study/NCT06207305) | A Phase I/II Study of Intraperitoneal Paclitaxel in Patients With Metastatic Appendiceal Adenocarcinoma | PHASE1 | M.D. Anderson Cancer Center | RECRUITING |
[NCT05734430](https://clinicaltrials.gov/study/NCT05734430) | Genetics of Appendix Cancer Study | — | Andreana Holowatyj, PhD, MSCI | RECRUITING |
[NCT03074513](https://clinicaltrials.gov/study/NCT03074513) | Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors | PHASE2 | M.D. Anderson Cancer Center | ACTIVE_NOT_RECRUITING |
[NCT06399757](https://clinicaltrials.gov/study/NCT06399757) | A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors | PHASE1 | Apollo Therapeutics Ltd | ACTIVE_NOT_RECRUITING |
94 publications have been identified in PubMed for appendix adenocarcinoma. Research spans Case Report / Case Series (32%), Epidemiology / Natural History (16%), and Review / Meta-Analysis (15%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 30 | 32% |
Disease patterns and progression | 15 | 16% |
Research summaries | 14 | 15% |
Clinical study results | 11 | 12% |
Laboratory research | 10 | 11% |
Testing and diagnosis research | 8 | 9% |
Other research | 3 | 3% |
New treatment approaches | 3 | 3% |
Aziz O (2026). [PMID: 42081249](https://pubmed.ncbi.nlm.nih.gov/42081249/). *JAMA Netw Open*. [Diagnostic / Biomarker]
Pattalachinti VK (2026). [PMID: 42081241](https://pubmed.ncbi.nlm.nih.gov/42081241/). *JAMA Netw Open*. [Clinical Trial Publication]
Xu X (2026). [PMID: 41116615](https://pubmed.ncbi.nlm.nih.gov/41116615/). *Expert Rev Anticancer Ther*. [Diagnostic / Biomarker]
Ramadan S (2026). [PMID: 41482399](https://pubmed.ncbi.nlm.nih.gov/41482399/). *In Vivo*. [Review / Meta-Analysis]
Chowdhury S (2026). [PMID: 41993359](https://pubmed.ncbi.nlm.nih.gov/41993359/). *bioRxiv*. [Epidemiology / Natural History]
Mahmoud A (2026). [PMID: 42190666](https://pubmed.ncbi.nlm.nih.gov/42190666/). *Dev Cell*. [Basic Science / Preclinical]
Sugarbaker PH (2026). [PMID: 42098056](https://pubmed.ncbi.nlm.nih.gov/42098056/). *J Surg Oncol*. [Review / Meta-Analysis]
Leiritz E (2026). [PMID: 41545608](https://pubmed.ncbi.nlm.nih.gov/41545608/). *Ann Surg Oncol*. [Diagnostic / Biomarker]
Pluim Z (2026). [PMID: 41988614](https://pubmed.ncbi.nlm.nih.gov/41988614/). *Cureus*. [Case Report / Case Series]
Leiritz E (2026). [PMID: 41501591](https://pubmed.ncbi.nlm.nih.gov/41501591/). *Ann Surg Oncol*. [Clinical Trial Publication]