KRAS encodes KRAS proto-oncogene, GTPase (189 aa). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Highest expression in Nerve Tibial (30.7 TPM) and Brain Cerebellar Hemisphere (25.1 TPM).

Arteriovenous malformations of the brain is associated with mutations in the KRAS gene on chromosome 12.

KRAS is classified as a druggable target (Clinically Actionable, Drug Resistance, and Enzyme categories) with score 1.0.

Genetic testing for KRAS is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for arteriovenous malformations of the brain has been reported in the published literature.

Phenotype severity distribution: 3 very common features, 6 common features.

Estimated prevalence: 1-9 in 100,000 (Uncommon).

7 clinical trials registered, 4 recruiting. Interventions under study include other interventions and medical devices. Pipeline includes 1 NA. Research is sponsored by a mix of industry and academic institutions.

125 publications have been identified in PubMed for arteriovenous malformations of the brain. Research spans Case Report / Case Series (35%), Basic Science / Preclinical (22%), and Epidemiology / Natural History (12%).

Recent Publications

• Dong X (2026). [PMID: 41811125](https://pubmed.ncbi.nlm.nih.gov/41811125/). *CNS neuroscience & therapeutics*. [Case Report / Case Series]

• Park H (2026). [PMID: 41642659](https://pubmed.ncbi.nlm.nih.gov/41642659/). *JCI insight*. [Basic Science / Preclinical]

• Liu J (2026). [PMID: 41521146](https://pubmed.ncbi.nlm.nih.gov/41521146/). *The Journal of international medical research*. [Clinical Trial Publication]

• Haver J (2026). [PMID: 42150201](https://pubmed.ncbi.nlm.nih.gov/42150201/). *J Neurosurg Case Lessons*. [Case Report / Case Series]

• Park JE (2026). [PMID: 41696778](https://pubmed.ncbi.nlm.nih.gov/41696778/). *Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism*. [Basic Science / Preclinical]

• Das S (2026). [PMID: 39513431](https://pubmed.ncbi.nlm.nih.gov/39513431/). *British journal of neurosurgery*. [Case Report / Case Series]

• Nascimento VS (2026). [PMID: 42119987](https://pubmed.ncbi.nlm.nih.gov/42119987/). *Arq Neuropsiquiatr*. [Epidemiology / Natural History]

• Park JI (2026). [PMID: 41582459](https://pubmed.ncbi.nlm.nih.gov/41582459/). *Journal of Korean Neurosurgical Society*. [Diagnostic / Biomarker]

• Naylor RM (2026). [PMID: 41172372](https://pubmed.ncbi.nlm.nih.gov/41172372/). *Journal of neurosurgery*. [Gene Therapy / Novel Therapeutics]

• Zeng Y (2026). [PMID: 42126442](https://pubmed.ncbi.nlm.nih.gov/42126442/). *Childs Nerv Syst*. [Review / Meta-Analysis]