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atrial conduction disease - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

atrial conduction disease

MONDO:0014500

Also known as:CARDIAC conduction disease with or without dilated cardiomyopathyCCDDfamilial atrial tachyarrhythmia-infra-Hisian cardiac conduction disease

Overview

Atrial conduction disorder is a form of heart disease in which the conduction of the cardiac atrium is disrupted.

GeneticsAutosomal dominant · TNNI3K (chr 1)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include sometimes findings: Congestive heart failure; and rarely findings: Cardiac arrest. 13 total HPO annotations.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	11	Paroxysmal supraventricular tachycardia, Cardiac arrest, Atrial arrhythmia

Genetic Landscape

TNNI3K function has not been fully characterized.

Atrial conduction disease is associated with mutations in the TNNI3K gene on chromosome 1.

Diagnosis

Genetic testing for TNNI3K is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for atrial conduction disease has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for atrial conduction disease.

240 publications have been identified in PubMed for atrial conduction disease. Research spans Basic Science / Preclinical (32%), Epidemiology / Natural History (23%), and Review / Meta-Analysis (18%).

Research Type	Count	% of Total
Laboratory research	76	32%

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 3:40 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:616117

Orphanet

European rare disease database

Orphanet:436242

GARD

Genetic and Rare Diseases Info Center

GARD:17729

Questions for Your Care Team

→Should I pursue genetic testing for TNNI3K, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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atrial conduction disease

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

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atrial conduction disease

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

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