Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

atrial fibrillation, familial, 10 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

atrial fibrillation, familial, 10

MONDO:0013530

Also known as:SCN5A familial atrial fibrillationatrial fibrillation, familial, type 10familial atrial fibrillation caused by mutation in SCN5A

Overview

Any familial atrial fibrillation in which the cause of the disease is a mutation in the SCN5A gene.

GeneticsAutosomal dominant · SCN5A (chr 3)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Tricuspid regurgitation; and very common findings: Bradycardia. 9 total HPO annotations.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	8	Permanent atrial fibrillation, Stroke, Bradycardia

Genetic Landscape

SCN5A function has not been fully characterized.

Atrial fibrillation, familial, 10 is associated with mutations in the SCN5A gene on chromosome 3.

Diagnosis

Genetic testing for SCN5A is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for atrial fibrillation, familial, 10 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 always present feature, 1 very common feature, 5 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for atrial fibrillation, familial, 10.

312 publications have been identified in PubMed for atrial fibrillation, familial, 10. Kisho has analyzed 136 by research type. Research spans Epidemiology / Natural History (31%), Review / Meta-Analysis (19%), and Other (18%).

Research Type	Count	% of Total
Disease patterns and progression	42	31%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 4:33 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:614022

GARD

Genetic and Rare Diseases Info Center

GARD:15745

Questions for Your Care Team

→Should I pursue genetic testing for SCN5A, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Kisho

atrial fibrillation, familial, 10

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

atrial fibrillation, familial, 10

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications