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atrial fibrillation, familial, 14 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

atrial fibrillation, familial, 14

MONDO:0014156

Also known as:SCN2B familial atrial fibrillationatrial fibrillation, familial, type 14familial atrial fibrillation caused by mutation in SCN2B

Overview

Any familial atrial fibrillation in which the cause of the disease is a mutation in the SCN2B gene.

GeneticsAutosomal dominant · SCN2B (chr 11)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: ST segment elevation and Paroxysmal atrial fibrillation; and common findings: Hypertension and Prolonged PR interval.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	2	Hypertension, Paroxysmal atrial fibrillation

Explore clinical features

Genetic Landscape

SCN2B function has not been fully characterized.

Atrial fibrillation, familial, 14 is associated with mutations in the SCN2B gene on chromosome 11.

Diagnosis

Genetic testing for SCN2B is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for atrial fibrillation, familial, 14 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 2 always present features, 2 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for atrial fibrillation, familial, 14.

286 publications have been identified in PubMed for atrial fibrillation, familial, 14. Kisho has analyzed 73 by research type. Research spans Epidemiology / Natural History (47%), Clinical Trial Publication (32%), and Review / Meta-Analysis (11%).

Research Type	Count	% of Total
Disease patterns and progression	34	47%

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 8:28 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:615378

GARD

Genetic and Rare Diseases Info Center

GARD:15955

Questions for Your Care Team

→Should I pursue genetic testing for SCN2B, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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atrial fibrillation, familial, 14

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

GARD

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Questions for Your Care Team

Questions for Your Care Team

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