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atypical chronic myeloid leukemia, BCR-ABL1 negative (aCML) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

atypical chronic myeloid leukemia, BCR-ABL1 negative

MONDO:0004653

Also known as:aCMLatypical CMLatypical chronic myeloid leukaemia

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Overview

A myelodysplastic/myeloproliferative neoplasm characterized by the principal involvement of the neutrophil series with leukocytosis and multilineage dysplasia. The neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion gene. (WHO, 2001)

Clinical Trials13 registered · 5 recruiting

ResearchLimited published research (6 articles)

Diagnosis

Biomarker and diagnostic research for atypical chronic myeloid leukemia, BCR-ABL1 negative has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

13 clinical trials registered, 5 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 5 PHASE2, 3 PHASE1, 1 EARLY_PHASE1. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07238712](https://clinicaltrials.gov/study/NCT07238712)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 3:37 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Financial & Access Support (External Programs)

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Medical References

External Resources

Orphanet

European rare disease database

Orphanet:98824

GARD

Genetic and Rare Diseases Info Center

GARD:19583

Questions for Your Care Team

→Are any of the 13 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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atypical chronic myeloid leukemia, BCR-ABL1 negative

Overview

Diagnosis

Research Landscape

Patient Support

Financial & Access Support (External Programs)

Are you a patient organization for this condition?

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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