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autosomal dominant prognathism - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

autosomal dominant prognathism

MONDO:0008312

Also known as:'Habsburg jaw''Hapsburg jaw'Habsburg jaw

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Overview

Malocclusion in which the mandible is anterior to the maxilla as reflected by the first relationship of the first permanent molar (mesioclusion).

GeneticsAutosomal dominant

Clinical Trials3 registered · 1 recruiting

ResearchLimited published research (2 articles)

Clinical Presentation

Features include sometimes findings: Craniosynostosis. 4 total HPO annotations.

Organ System	Phenotype Count	Example Features
Head and neck	3	Craniosynostosis, Thick lower lip vermilion, Mandibular prognathia

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Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.

4 publications have been identified in PubMed for autosomal dominant prognathism. Kisho has analyzed 2 by research type. Research spans Review / Meta-Analysis (50%) and Case Report / Case Series (50%).

Recent Publications

Dehesa-Santos A (2025). [PMID: 41263672](https://pubmed.ncbi.nlm.nih.gov/41263672/). *Orthod Craniofac Res*. [Review / Meta-Analysis]
Singh N (2024). [PMID: 39013624](https://pubmed.ncbi.nlm.nih.gov/39013624/). *BMJ Case Rep*. [Case Report / Case Series]

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 6:45 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:176700

Orphanet

European rare disease database

Orphanet:2964

GARD

Genetic and Rare Diseases Info Center

GARD:10319

Questions for Your Care Team

→Are any of the 3 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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autosomal dominant prognathism

Overview

Clinical Presentation

Explore clinical features

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team