GIPC3 encodes GIPC PDZ domain containing family member 3 (312 aa). Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion Highest expression in Esophagus Muscularis (14.9 TPM) and Lung (8.0 TPM).

Autosomal recessive nonsyndromic hearing loss 15 is associated with mutations in the GIPC3 gene on chromosome 19.

GIPC3 is classified as a druggable target with score 0.0.

Genetic testing for GIPC3 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for autosomal recessive nonsyndromic hearing loss 15 has been reported in the published literature.

Phenotype severity distribution: 2 always present features.

No clinical trials have been registered for autosomal recessive nonsyndromic hearing loss 15.

30 publications have been identified in PubMed for autosomal recessive nonsyndromic hearing loss 15. Research spans Case Report / Case Series (23%), Basic Science / Preclinical (20%), and Epidemiology / Natural History (20%).

Recent Publications

• Huynh BC (2026). [PMID: 41845931](https://pubmed.ncbi.nlm.nih.gov/41845931/). *Ophthalmic Genet*. [Basic Science / Preclinical]

• Theunis M (2026). [PMID: 41126390](https://pubmed.ncbi.nlm.nih.gov/41126390/). *Ophthalmic Genet*. [Review / Meta-Analysis]

• Issa K (2026). [PMID: 41948131](https://pubmed.ncbi.nlm.nih.gov/41948131/). *Sage Open Pediatr*. [Case Report / Case Series]

• Abati E (2026). [PMID: 42089726](https://pubmed.ncbi.nlm.nih.gov/42089726/). *J Neuromuscul Dis*. [Review / Meta-Analysis]

• Ding Y (2025). [PMID: 40195191](https://pubmed.ncbi.nlm.nih.gov/40195191/). *Eur Arch Otorhinolaryngol*. [Diagnostic / Biomarker]

• Qi J (2025). [PMID: 40603731](https://pubmed.ncbi.nlm.nih.gov/40603731/). *Nat Med*. [Clinical Trial Publication]

• Janky KL (2025). [PMID: 40420514](https://pubmed.ncbi.nlm.nih.gov/40420514/). *J Am Acad Audiol*. [Epidemiology / Natural History]

• Cheon TU (2025). [PMID: 41461707](https://pubmed.ncbi.nlm.nih.gov/41461707/). *Sci Rep*. [Diagnostic / Biomarker]

• Long X (2025). [PMID: 40410890](https://pubmed.ncbi.nlm.nih.gov/40410890/). *Hum Genomics*. [Basic Science / Preclinical]

• Damrongchietanon T (2025). [PMID: 40998904](https://pubmed.ncbi.nlm.nih.gov/40998904/). *Sci Rep*. [Diagnostic / Biomarker]