GRXCR1 encodes glutaredoxin and cysteine rich domain containing 1 (290 aa). May play a role in actin filament architecture in developing stereocilia of sensory cells Highest expression in Testis (0.6 TPM) and Brain Nucleus accumbens basal ganglia (0.0 TPM).

Autosomal recessive nonsyndromic hearing loss 25 is associated with mutations in the GRXCR1 gene on chromosome 4.

GRXCR1 is classified as a druggable target with score 0.0.

Genetic testing for GRXCR1 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for autosomal recessive nonsyndromic hearing loss 25 has been reported in the published literature.

Phenotype severity distribution: 1 always present feature, 1 common feature.

No clinical trials have been registered for autosomal recessive nonsyndromic hearing loss 25.

19 publications have been identified in PubMed for autosomal recessive nonsyndromic hearing loss 25. Kisho has analyzed 13 by research type. Research spans Case Report / Case Series (54%), Review / Meta-Analysis (23%), and Basic Science / Preclinical (15%).

Recent Publications

• Samara P (2026). [PMID: 41594276](https://pubmed.ncbi.nlm.nih.gov/41594276/). *Diagnostics (Basel)*. [Case Report / Case Series]

• Gan H (2026). [PMID: 41578500](https://pubmed.ncbi.nlm.nih.gov/41578500/). *Medicine (Baltimore)*. [Case Report / Case Series]

• Elander J (2025). [PMID: 40685639](https://pubmed.ncbi.nlm.nih.gov/40685639/). *J Otolaryngol Head Neck Surg*. [Diagnostic / Biomarker]

• Wang H (2025). [PMID: 40677926](https://pubmed.ncbi.nlm.nih.gov/40677926/). *Hum Mutat*. [Case Report / Case Series]

• Marucci A (2025). [PMID: 40603556](https://pubmed.ncbi.nlm.nih.gov/40603556/). *Diabetologia*. [Basic Science / Preclinical]

• Guillouet C (2025). [PMID: 40081376](https://pubmed.ncbi.nlm.nih.gov/40081376/). *Am J Hum Genet*. [Basic Science / Preclinical]

• Demirtaş B (2024). [PMID: 39128043](https://pubmed.ncbi.nlm.nih.gov/39128043/). *J Int Adv Otol*. [Case Report / Case Series]

• Marfatia H (2024). [PMID: 39716816](https://pubmed.ncbi.nlm.nih.gov/39716816/). *Cochlear Implants Int*. [Case Report / Case Series]

• Hu M (2024). [PMID: 39095761](https://pubmed.ncbi.nlm.nih.gov/39095761/). *BMC Pediatr*. [Case Report / Case Series]

• Jurca AD (2024). [PMID: 39064493](https://pubmed.ncbi.nlm.nih.gov/39064493/). *Medicina (Kaunas)*. [Review / Meta-Analysis]