MYO6 encodes myosin VI (1,294 aa). Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Highest expression in Lung (31.4 TPM) and Kidney Medulla (29.8 TPM).

Autosomal recessive nonsyndromic hearing loss 37 is associated with mutations in the MYO6 gene on chromosome 6.

MYO6 is classified as a druggable target with score 0.0.

Genetic testing for MYO6 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for autosomal recessive nonsyndromic hearing loss 37 has been reported in the published literature.

Phenotype severity distribution: 1 always present feature.

No clinical trials have been registered for autosomal recessive nonsyndromic hearing loss 37.

13 publications have been identified in PubMed for autosomal recessive nonsyndromic hearing loss 37. Research spans Basic Science / Preclinical (31%), Diagnostic / Biomarker (23%), and Gene Therapy / Novel Therapeutics (23%).

Recent Publications

• Jiang L (2026). [PMID: 42020731](https://pubmed.ncbi.nlm.nih.gov/42020731/). *Nature*. [Gene Therapy / Novel Therapeutics]

• Balatková Z (2026). [PMID: 41884524](https://pubmed.ncbi.nlm.nih.gov/41884524/). *Otology & neurotology open*. [Basic Science / Preclinical]

• Seki Y (2025). [PMID: 39694491](https://pubmed.ncbi.nlm.nih.gov/39694491/). *Experimental animals*. [Basic Science / Preclinical]

• Colbert BM (2025). [PMID: 39560289](https://pubmed.ncbi.nlm.nih.gov/39560289/). *The Laryngoscope*. [Diagnostic / Biomarker]

• Kim JA (2025). [PMID: 40164689](https://pubmed.ncbi.nlm.nih.gov/40164689/). *Experimental & molecular medicine*. [Diagnostic / Biomarker]

• Ding Y (2025). [PMID: 40195191](https://pubmed.ncbi.nlm.nih.gov/40195191/). *European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery*. [Diagnostic / Biomarker]

• Wu F (2025). [PMID: 40538303](https://pubmed.ncbi.nlm.nih.gov/40538303/). *Advanced science (Weinheim, Baden-Wurttemberg, Germany)*. [Gene Therapy / Novel Therapeutics]

• Marucci A (2025). [PMID: 40603556](https://pubmed.ncbi.nlm.nih.gov/40603556/). *Diabetologia*. [Case Report / Case Series]

• Niehues T (2024). [PMID: 39381601](https://pubmed.ncbi.nlm.nih.gov/39381601/). *Allergologie select*. [Case Report / Case Series]

• Köse E (2024). [PMID: 38382588](https://pubmed.ncbi.nlm.nih.gov/38382588/). *European journal of medical genetics*. [Epidemiology / Natural History]