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Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava.
Features include very common findings: Portal hypertension, Ascites, and Enlarged spleen (splenomegaly); and common findings: Liver scarring (cirrhosis) (cirrhosis), Fever, Abdominal pain, and Esophageal varix and others. 25 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Digestive system | 16 | Liver scarring (cirrhosis) (cirrhosis), Hepatocellular carcinoma, Ascites |
Biomarker and diagnostic research for Budd-Chiari syndrome has been reported in the published literature.
Phenotype severity distribution: 3 very common features, 9 common features.
Estimated prevalence: 1-9 in 100,000 (Uncommon).
2 clinical trials registered. Interventions under study include medical devices. Pipeline includes 1 NA. Research is primarily sponsored by academic and government institutions.
208 publications have been identified in PubMed for Budd-Chiari syndrome. Kisho has analyzed 80 by research type. Research spans Review / Meta-Analysis (34%), Case Report / Case Series (31%), and Epidemiology / Natural History (15%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 27 |
Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 4:30 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Budd-Chiari syndrome
Lab test results |
2 |
Elevated circulating hepatic transaminase concentration, Elevated circulating alkaline phosphatase concentration |
Heart and blood vessels | 1 | Portal hypertension |
Blood and immune system | 1 | Enlarged spleen (splenomegaly) |
Metabolism | 1 | Fever |
Kidneys and urinary system | 1 | Reduced kidney function (renal insufficiency) |
Growth and development | 1 | Weight loss |
Brain and nerves | 1 | Hepatic encephalopathy |
Patient case studies | 25 | 31% |
Disease patterns and progression | 12 | 15% |
Clinical study results | 8 | 10% |
Testing and diagnosis research | 5 | 6% |
Laboratory research | 3 | 4% |
Girish V (2026). [PMID: 29493996](https://pubmed.ncbi.nlm.nih.gov/29493996/). *Unknown Journal*. [Epidemiology / Natural History]
Bettinger D (2026). [PMID: 41587551](https://pubmed.ncbi.nlm.nih.gov/41587551/). *Z Gastroenterol*. [Review / Meta-Analysis]
Mukund A (2026). [PMID: 41947698](https://pubmed.ncbi.nlm.nih.gov/41947698/). *Liver Int*. [Epidemiology / Natural History]
Giri S (2026). [PMID: 41019147](https://pubmed.ncbi.nlm.nih.gov/41019147/). *Journal of clinical and experimental hepatology*. [Review / Meta-Analysis]
Morales-Cruz X (2026). [PMID: 40875675](https://pubmed.ncbi.nlm.nih.gov/40875675/). *Dig Dis*. [Epidemiology / Natural History]
Daza J (2026). [PMID: 41729746](https://pubmed.ncbi.nlm.nih.gov/41729746/). *Digestive diseases (Basel, Switzerland)*. [Diagnostic / Biomarker]
Jiang T (2026). [PMID: 41299854](https://pubmed.ncbi.nlm.nih.gov/41299854/). *J Clin Ultrasound*. [Case Report / Case Series]
Unknown (2026). [PMID: 41224629](https://pubmed.ncbi.nlm.nih.gov/41224629/). *Journal of hepatology*. [Review / Meta-Analysis]
Narang M (2026). [PMID: 41140476](https://pubmed.ncbi.nlm.nih.gov/41140476/). *J Clin Exp Hepatol*. [Review / Meta-Analysis]
Röhlen N (2025). [PMID: 40086863](https://pubmed.ncbi.nlm.nih.gov/40086863/). *Deutsche medizinische Wochenschrift (1946)*. [Review / Meta-Analysis]
AI-curated news mentioning Budd-Chiari syndrome
Updated Sep 15, 2026
Recent research highlights the use of liver and spleen stiffness measurements as effective non-invasive tools for assessing liver congestion in patients with Budd-Chiari syndrome. This study could enhance diagnostic approaches and patient management strategies.
A recent study investigates the link between systemic inflammation indices and recurrence risk in primary Budd-Chiari syndrome. Findings may provide insights into patient management and risk stratification.
A systematic review on pediatric Budd-Chiari syndrome highlights key insights into its etiology, diagnosis, and management strategies. This comprehensive analysis aims to improve understanding and treatment approaches for this rare condition.