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calcaneonavicular coalition - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

calcaneonavicular coalition

MONDO:0008518

Also known as:multiple synostosis syndromesynostoses, tarsal, carpal and digitalsynostoses, tarsal, carpal, and digital

Overview

A synostosis characterized by the fusion of carpal and tarsal bones, which causes stiffness and immobility of the hands and the feet.

GeneticsAutosomal dominant

ResearchLimited published research (9 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Radial head subluxation, Underdeveloped nasal alae, Metacarpophalangeal synostosis, and Short metacarpal and 4 more.

Organ System	Phenotype Count	Example Features
Arms and legs	1	Aplasia/Hypoplasia of the middle phalanges of the hand

Explore clinical features

Diagnosis

Biomarker and diagnostic research for calcaneonavicular coalition has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for calcaneonavicular coalition.

10 publications have been identified in PubMed for calcaneonavicular coalition. Research spans Epidemiology / Natural History (33%), Case Report / Case Series (22%), and Clinical Trial Publication (22%).

Recent Publications

Loria-Avila E (2026). [PMID: 42247889](https://pubmed.ncbi.nlm.nih.gov/42247889/). *Foot (Edinb)*. [Review / Meta-Analysis]
Motwani G (2026). [PMID: 41970743](https://pubmed.ncbi.nlm.nih.gov/41970743/). *J Orthop Case Rep*. [Case Report / Case Series]
Nash A (2025). [PMID: 40183211](https://pubmed.ncbi.nlm.nih.gov/40183211/). *J Pediatr Orthop*. [Epidemiology / Natural History]
Fernández-Rojas E (2025). [PMID: 39984120](https://pubmed.ncbi.nlm.nih.gov/39984120/). *Rev Esp Cir Ortop Traumatol*. [Epidemiology / Natural History]
Fernández-Rojas E (2025). [PMID: 39343135](https://pubmed.ncbi.nlm.nih.gov/39343135/). *Rev Esp Cir Ortop Traumatol*. [Epidemiology / Natural History]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 3:31 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:186400

GARD

Genetic and Rare Diseases Info Center

GARD:9863

Questions for Your Care Team

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calcaneonavicular coalition

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team