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cancer-associated retinopathy - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

cancer-associated retinopathy

MONDO:0019112

Also known as:CAR syndromeparaneoplastic retinopathy

Overview

Cancer associated retinopathy (CAR) is a paraneoplastic disease of the eye associated with the presence of extraocular malignancy and circulating autoantibodies against retinal proteins.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include common findings: Visual loss, Photophobia, Malignant genitourinary tract tumor, and Reduced visual acuity and others; and sometimes findings: Optic disc pallor, Central scotoma, Retinal atrophy, and Constriction of peripheral visual field and others. 35 total HPO annotations.

Organ System	Phenotype Count	Example Features
Eyes	7	Adult-onset night blindness, Optic disc pallor, Retinal atrophy

Diagnosis

Biomarker and diagnostic research for cancer-associated retinopathy has been reported in the published literature.

Prognosis

Phenotype severity distribution: 12 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for cancer-associated retinopathy.

46 publications have been identified in PubMed for cancer-associated retinopathy. Research spans Case Report / Case Series (70%), Review / Meta-Analysis (22%), and Diagnostic / Biomarker (4%).

Research Type	Count	% of Total
Patient case studies	32	70%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:47 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:71505

GARD

Genetic and Rare Diseases Info Center

GARD:18912

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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Kisho

cancer-associated retinopathy

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

cancer-associated retinopathy

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications