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candidiasis, familial, 6 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

candidiasis, familial, 6

MONDO:0013503

Also known as:IL17F familial chronic mucocutaneous candidiasiscandidiasis, familial, 6, autosomal dominantcandidiasis, familial, type 6

Overview

Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene.

GeneticsAutosomal dominant · IL17F (chr 6)

Clinical Presentation

Features include: Chronic mucocutaneous candidiasis.

Explore clinical features

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

IL17F encodes interleukin 17F (163 aa). Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Highest expression in Testis (1.2 TPM) and Brain Cerebellum (0.1 TPM).

Candidiasis, familial, 6 is associated with mutations in the IL17F gene on chromosome 6.

The IL17F protein participates in Expression of STAT3-upregulated extracellular proteins and Differentiation of T cells pathways.

IL17F is classified as a druggable target (Druggable Genome category) with score 7.5.

Diagnosis

Genetic testing for IL17F is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for candidiasis, familial, 6 has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for candidiasis, familial, 6.

40 publications have been identified in PubMed for candidiasis, familial, 6. Research spans Basic Science / Preclinical (28%), Review / Meta-Analysis (20%), and Clinical Trial Publication (15%).

Research Type	Count	% of Total
Laboratory research	11	28%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 1:05 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:613956

GARD

Genetic and Rare Diseases Info Center

GARD:15093

Questions for Your Care Team

→Should I pursue genetic testing for IL17F, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

candidiasis, familial, 6

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Surveillance for invasive candidiasis in China (CHIF-NET 2018-2021): rising antifungal resistance observed in a nationwide longitudinal study.

candidiasis, familial, 6

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Surveillance for invasive candidiasis in China (CHIF-NET 2018-2021): rising antifungal resistance observed in a nationwide longitudinal study.