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An aggressive malignant mixed epithelial and mesenchymal tumor that arises from the uterine corpus. It usually affects elderly postmenopausal women and presents with vaginal bleeding. It is characterized by the presence of a malignant epithelial component that is usually glandular and a sarcomatous component.
Biomarker and diagnostic research for carcinosarcoma of the corpus uteri has been reported in the published literature.
10 clinical trials registered, 2 recruiting. Interventions under study include drug therapy, procedural interventions, other interventions, and biologic therapy. Pipeline includes 1 PHASE3, 4 PHASE2, 4 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT03686124](https://clinicaltrials.gov/study/NCT03686124) | ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors | PHASE1 | Immatics US, Inc. | RECRUITING |
[NCT07029399](https://clinicaltrials.gov/study/NCT07029399) | A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors | PHASE1 | NiKang Therapeutics, Inc. | RECRUITING |
91 publications have been identified in PubMed for carcinosarcoma of the corpus uteri. Research spans Case Report / Case Series (25%), Epidemiology / Natural History (21%), and Basic Science / Preclinical (18%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 23 | 25% |
Disease patterns and progression | 19 | 21% |
Laboratory research | 16 | 18% |
Clinical study results | 13 | 14% |
Research summaries | 8 | 9% |
Testing and diagnosis research | 7 |
Subhash S (2026). [PMID: 42079274](https://pubmed.ncbi.nlm.nih.gov/42079274/). *bioRxiv*. [Basic Science / Preclinical]
Bahmad HF (2026). [PMID: 41915930](https://pubmed.ncbi.nlm.nih.gov/41915930/). *International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists*. [Diagnostic / Biomarker]
Iida Y (2026). [PMID: 41947901](https://pubmed.ncbi.nlm.nih.gov/41947901/). *Oncol Lett*. [Case Report / Case Series]
Dzienny A (2026). [PMID: 42095053](https://pubmed.ncbi.nlm.nih.gov/42095053/). *Gynecol Oncol Rep*. [Epidemiology / Natural History]
Vallejo-Soto JC (2026). [PMID: 41559694](https://pubmed.ncbi.nlm.nih.gov/41559694/). *BMC surgery*. [Case Report / Case Series]
More AK (2026). [PMID: 41859487](https://pubmed.ncbi.nlm.nih.gov/41859487/). *Clinical case reports*. [Basic Science / Preclinical]
Shen H (2026). [PMID: 42032425](https://pubmed.ncbi.nlm.nih.gov/42032425/). *Discov Oncol*. [Case Report / Case Series]
Waeldner K (2026). [PMID: 41583123](https://pubmed.ncbi.nlm.nih.gov/41583123/). *Case reports in women's health*. [Epidemiology / Natural History]
Yang Y (2026). [PMID: 41983511](https://pubmed.ncbi.nlm.nih.gov/41983511/). *J Pathol*. [Gene Therapy / Novel Therapeutics]
Keser M (2026). [PMID: 41514389](https://pubmed.ncbi.nlm.nih.gov/41514389/). *BMC cancer*. [Case Report / Case Series]
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:04 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
New treatment approaches | 5 | 5% |