Carney complex - trismus - pseudocamptodactyly syndrome is a rare genetic condition that affects both the heart and the hands. It is part of the Carney complex spectrum, which includes features like spotty skin pigmentation, heart tumors (myxomas), skin tumors, and issues with hormone-producing glands (endocrinopathy). In this syndrome, individuals also experience trismus, which is the involuntary contraction of the jaw muscles, and pseudocamptodactyly or distal arthrogryposis. This means that the finger joints and sometimes joints in the feet may contract or become less flexible when the wrists or feet are moved in certain directions.

People with this condition may show signs common to Carney complex, such as irregular skin spots and cardiac or skin tumors. In addition, they can experience trismus (difficulty opening the jaw) and joint contractures in the hands and feet, which may become more noticeable when the wrists or ankles are moved.

Carney complex - trismus - pseudocamptodactyly syndrome is genetic. It is linked to changes in the MYH8 gene, which can affect muscle function and development. This condition’s genetic nature means it may run in families, and the gene change is associated with the unique mix of heart, skin, and joint issues seen in the syndrome. Associated genes include MYH8.