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cerebral amyloid angiopathy (HCHWA) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

cerebral amyloid angiopathy

MONDO:0005620

Also known as:HCHWAdutch hereditary cerebral amyloid angiopathyhereditary cerebral haemorrhage with amyloidosis - Dutch type

Find Clinical TrialsTrials

Overview

Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.

Clinical Trials13 registered · 7 recruiting

Diagnosis

Biomarker and diagnostic research for cerebral amyloid angiopathy has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

13 clinical trials registered, 7 recruiting. Interventions under study include drug therapy, other interventions, and medical devices. Pipeline includes 1 PHASE3, 4 PHASE2, 1 NA. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07250035](https://clinicaltrials.gov/study/NCT07250035)

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:13 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:85458

GARD

Genetic and Rare Diseases Info Center

GARD:10266

Questions for Your Care Team

→Are any of the 13 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Research summaries	60	26%
Laboratory research	60	26%
Disease patterns and progression	38	16%
Testing and diagnosis research	30	13%
Patient case studies	25	11%
Other research	10	4%
Clinical study results	8	3%
New treatment approaches	2	1%

Kisho

cerebral amyloid angiopathy

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Distinct characteristics and risk factors of symptomatic and incidental DWI lesions in cerebral amyloid angiopathy.

Brain iron, cortical atrophy and cognition impairment in cerebral amyloid angiopathy: A quantitative susceptibility mapping study.

Amyloid PET Burden, CSF Biomarkers, and APOE Genotype in People With Iatrogenic and Sporadic Cerebral Amyloid Angiopathy.

cerebral amyloid angiopathy

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Distinct characteristics and risk factors of symptomatic and incidental DWI lesions in cerebral amyloid angiopathy.

Brain iron, cortical atrophy and cognition impairment in cerebral amyloid angiopathy: A quantitative susceptibility mapping study.

Amyloid PET Burden, CSF Biomarkers, and APOE Genotype in People With Iatrogenic and Sporadic Cerebral Amyloid Angiopathy.