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childhood disintegrative disorder - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

childhood disintegrative disorder

MONDO:0015681

Also known as:dementia infantilisdisintegrative psychosisheller syndrome

Overview

A rare pervasive developmental disorder with a disease onset before the age of three and characterized by a dramatic loss of behavioral and developmental functioning after atleast two years of normal development. Manifestations of the disease include loss of speech, incontinence, communication and social interaction problems, stereotypical autistic behaviors and dementia.

ResearchLimited published research (4 articles)

Prognosis

Estimated prevalence: 1-9 in 100,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for childhood disintegrative disorder.

6 publications have been identified in PubMed for childhood disintegrative disorder. Kisho has analyzed 4 by research type. Research spans Case Report / Case Series (75%) and Epidemiology / Natural History (25%).

Recent Publications

Davoody S (2026). [PMID: 41806544](https://pubmed.ncbi.nlm.nih.gov/41806544/). *Journal of pediatric nursing*. [Case Report / Case Series]
Hazra S (2026). [PMID: 40591909](https://pubmed.ncbi.nlm.nih.gov/40591909/). *The journal of ECT*. [Case Report / Case Series]
Abraham SE (2025). [PMID: 39865989](https://pubmed.ncbi.nlm.nih.gov/39865989/). *BJPsych open*. [Case Report / Case Series]
Ito H (2025). [PMID: 41044354](https://pubmed.ncbi.nlm.nih.gov/41044354/). *Journal of anesthesia*. [Epidemiology / Natural History]

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 4:32 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:168782

GARD

Genetic and Rare Diseases Info Center

GARD:6040

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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childhood disintegrative disorder

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team