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A medulloblastoma occurring in children.
Biomarker and diagnostic research for childhood medulloblastoma has been reported in the published literature.
17 clinical trials registered, 13 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 2 PHASE3, 3 PHASE2, 6 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05298995](https://clinicaltrials.gov/study/NCT05298995) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:56 PM UTC
Genetic and Rare Diseases Info Center
GD2-CAR T Cells for Pediatric Brain Tumours |
PHASE1 |
Bambino Gesù Hospital and Research Institute |
RECRUITING |
[NCT04185038](https://clinicaltrials.gov/study/NCT04185038) | Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors | PHASE1 | Seattle Children's Hospital | RECRUITING |
[NCT06959979](https://clinicaltrials.gov/study/NCT06959979) | Novel Molecular Targets and Innovative Therapeutic Perspective in Medulloblastoma | EARLY_PHASE1 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | RECRUITING |
[NCT05382338](https://clinicaltrials.gov/study/NCT05382338) | A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss | PHASE3 | Children's Oncology Group | RECRUITING |
[NCT05057702](https://clinicaltrials.gov/study/NCT05057702) | Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma | NA | University of California, San Francisco | RECRUITING |
202 publications have been identified in PubMed for childhood medulloblastoma. Research spans Basic Science / Preclinical (42%), Review / Meta-Analysis (24%), and Epidemiology / Natural History (12%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 84 | 42% |
Research summaries | 49 | 24% |
Disease patterns and progression | 24 | 12% |
New treatment approaches | 22 | 11% |
Testing and diagnosis research | 9 | 4% |
Clinical study results | 9 | 4% |
Patient case studies | 5 | 2% |
Bernardi F (2026). [PMID: 41544627](https://pubmed.ncbi.nlm.nih.gov/41544627/). *Cancer cell*. [Diagnostic / Biomarker]
Bianchini L (2026). [PMID: 41929097](https://pubmed.ncbi.nlm.nih.gov/41929097/). *bioRxiv*. [Diagnostic / Biomarker]
Smith KS (2026). [PMID: 41159377](https://pubmed.ncbi.nlm.nih.gov/41159377/). *Neuro Oncol*. [Basic Science / Preclinical]
Arora S (2026). [PMID: 41159380](https://pubmed.ncbi.nlm.nih.gov/41159380/). *Neuro-oncology*. [Basic Science / Preclinical]
Draper B (2026). [PMID: 41652893](https://pubmed.ncbi.nlm.nih.gov/41652893/). *Neuro Oncol*. [Basic Science / Preclinical]
Sarvode S (2026). [PMID: 41712211](https://pubmed.ncbi.nlm.nih.gov/41712211/). *JAMA network open*. [Epidemiology / Natural History]
Ford N (2026). [PMID: 42130628](https://pubmed.ncbi.nlm.nih.gov/42130628/). *Front Oncol*. [Gene Therapy / Novel Therapeutics]
Kenkre R (2026). [PMID: 42210429](https://pubmed.ncbi.nlm.nih.gov/42210429/). *Genome Med*. [Basic Science / Preclinical]
Karsonovich T (2026). [PMID: 30571036](https://pubmed.ncbi.nlm.nih.gov/30571036/). *Unknown Journal*. [Basic Science / Preclinical]
Chen Y (2026). [PMID: 40889129](https://pubmed.ncbi.nlm.nih.gov/40889129/). *Eur J Cancer Prev*. [Basic Science / Preclinical]
AI-curated news mentioning childhood medulloblastoma
Updated Apr 17, 2026
Recent research highlights the role of PTEN in inhibiting SHH medulloblastoma growth via both cell autonomous and nonautonomous mechanisms. This discovery could inform future therapeutic strategies for this aggressive brain tumor.
A new study explores a high-dose chemotherapy and craniospinal irradiation-sparing approach for treating Group 4 medulloblastomas in early childhood. This research could influence future treatment protocols for this specific subtype of brain cancer.