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A rare chronic myeloproliferative neoplasm characterized by neutrophilic leukocytosis. There is no detectable Philadelphia chromosome or BCR/ABL fusion gene.
Biomarker and diagnostic research for chronic neutrophilic leukemia has been reported in the published literature.
8 clinical trials registered, 2 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and medical devices. Pipeline includes 2 PHASE2, 1 PHASE1, 1 EARLY_PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT03862157](https://clinicaltrials.gov/study/NCT03862157) |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 3:05 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about chronic neutrophilic leukemia
Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia |
PHASE1 |
M.D. Anderson Cancer Center |
ACTIVE_NOT_RECRUITING |
[NCT00935090](https://clinicaltrials.gov/study/NCT00935090) | 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer | — | Barbara Ann Karmanos Cancer Institute | ACTIVE_NOT_RECRUITING |
[NCT01137643](https://clinicaltrials.gov/study/NCT01137643) | Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer | — | UNC Lineberger Comprehensive Cancer Center | RECRUITING |
[NCT00544115](https://clinicaltrials.gov/study/NCT00544115) | Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders | PHASE2 | City of Hope Medical Center | ACTIVE_NOT_RECRUITING |
[NCT05177211](https://clinicaltrials.gov/study/NCT05177211) | Fedratinib in Myelodysplastic /Myeloproliferative Neoplasms (MDS/MPNs) and Chronic Neutrophilic Leukemia (CNL) | PHASE2 | H. Lee Moffitt Cancer Center and Research Institute | UNKNOWN |
36 publications have been identified in PubMed for chronic neutrophilic leukemia. Research spans Review / Meta-Analysis (39%), Case Report / Case Series (33%), and Basic Science / Preclinical (8%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 14 | 39% |
Patient case studies | 12 | 33% |
Laboratory research | 3 | 8% |
Disease patterns and progression | 3 | 8% |
Other research | 2 | 6% |
Testing and diagnosis research | 2 | 6% |
Haider MZ (2026). [PMID: 32809524](https://pubmed.ncbi.nlm.nih.gov/32809524/). *Unknown Journal*. [Basic Science / Preclinical]
Liao MY (2026). [PMID: 42227420](https://pubmed.ncbi.nlm.nih.gov/42227420/). *Zhongguo Shi Yan Xue Ye Xue Za Zhi*. [Diagnostic / Biomarker]
Wei Y (2026). [PMID: 41663192](https://pubmed.ncbi.nlm.nih.gov/41663192/). *Zhonghua Xue Ye Xue Za Zhi*. [Case Report / Case Series]
Thapa B (2026). [PMID: 30285359](https://pubmed.ncbi.nlm.nih.gov/30285359/). *Unknown Journal*. [Review / Meta-Analysis]
Mukae J (2026). [PMID: 41990562](https://pubmed.ncbi.nlm.nih.gov/41990562/). *Leuk Res*. [Other]
Bolarinwa AB (2026). [PMID: 42131931](https://pubmed.ncbi.nlm.nih.gov/42131931/). *Haematologica*. [Case Report / Case Series]
Maffei R (2025). [PMID: 39907800](https://pubmed.ncbi.nlm.nih.gov/39907800/). *Annals of hematology*. [Epidemiology / Natural History]
Hamoud M (2025). [PMID: 41390940](https://pubmed.ncbi.nlm.nih.gov/41390940/). *Expert opinion on pharmacotherapy*. [Review / Meta-Analysis]
Seth N (2025). [PMID: 40806796](https://pubmed.ncbi.nlm.nih.gov/40806796/). *Journal of clinical medicine*. [Case Report / Case Series]
Bonuomo V (2025). [PMID: 41228273](https://pubmed.ncbi.nlm.nih.gov/41228273/). *Cancers (Basel)*. [Review / Meta-Analysis]
AI-curated news mentioning chronic neutrophilic leukemia
Updated Aug 4, 2026
A study provides longitudinal molecular characterization of a rare myeloid/lymphoid neoplasm associated with TPM3::PDGFRB rearrangement. This research enhances understanding of the disease's evolution, particularly its late CNL-like neutrophilic features.